TIRP Blocking Peptide | TICAM2 blocking peptide

TIRP Peptide

Cat. Num. AAA153263

• Applications: Blocking (BL)
• Synonyms: TIRP; TIRP Peptide; TRAM; TIRAP3; MyD88-4; TICAM-2; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; toll-like receptor adaptor molecule 2; TICAM2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 235

• Applicable Applications for TICAM2 blocking peptide: Blocking (BL)
• Application Notes: TIRP peptide is used for blocking the activity of TIRP antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: Amino acids near the carboxy terminus of human TIRP.
• Preparation and Storage: Store TIRP peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 32435943
• NCBI GeneID: 100302736
• UniProt Accession #: Q86XR7; Q6JUT2; B3Y698
• Molecular Weight: 46,173 Da
• NCBI Official Full Name: TIR domain-containing adapter protein
• NCBI Official Synonym Full Names: TMED7-TICAM2 readthrough
• NCBI Official Symbol: TMED7-TICAM2
• NCBI Protein Information: TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript
• UniProt Protein Name: TIR domain-containing adapter molecule 2
• Protein Family: TIR domain-containing adapter molecule
• UniProt Gene Name: TICAM2
• UniProt Synonym Gene Names: TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
• UniProt Entry Name: TCAM2_HUMAN

NCBI Description

This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

Uniprot Description

TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; late endosome membrane; early endosome membrane; endoplasmic reticulum; early endosome; late endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway