Slug Blocking Peptide | SNAI2 blocking peptide

Slug Peptide

Cat. Num. AAA153101

• Gene Names: SNAI2; SLUG; WS2D; SLUGH1; SNAIL2
• Applications: Blocking (BL)
• Synonyms: Slug; Slug Peptide; SLUG; WS2D; SLUGH1; SNAIL2; SLUGH; Zinc finger protein SNAI2; Neural crest transcription factor Slug; snail homolog 2 (Drosophila); SNAI2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 268

• Applicable Applications for SNAI2 blocking peptide: Blocking (BL)
• Application Notes: Slug peptide is used for blocking activity of Slug antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 13 amino acids near the center of human Slug..
• Preparation and Storage: Store Slug peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 11134406
• NCBI GeneID: 6591
• UniProt Accession #: O43623; Q53FC1; B2R6P6
• Molecular Weight: 29,986 Da
• NCBI Official Full Name: Zinc finger protein SNAI2
• NCBI Official Synonym Full Names: snail family zinc finger 2
• NCBI Official Symbol: SNAI2
• NCBI Official Synonym Symbols: SLUG; WS2D; SLUGH1; SNAIL2
• NCBI Protein Information: zinc finger protein SNAI2; snail homolog 2; protein snail homolog 2; neural crest transcription factor SLUG; slug (chicken homolog), zinc finger protein
• UniProt Protein Name: Zinc finger protein SNAI2
• Protein Family: Zinc finger protein
• UniProt Gene Name: SNAI2
• UniProt Synonym Gene Names: SLUG; SLUGH
• UniProt Entry Name: SNAI2_HUMAN

NCBI Description

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

Uniprot Description

Snail2: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family.

Protein type: Apoptosis; Motility/polarity/chemotaxis; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: cytoplasm; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; metal ion binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; substrate-bound cell migration, cell release from substrate; regulation of osteoblast differentiation; neural crest cell development; negative regulation of chondrocyte differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; palate development; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; sensory perception of sound; pigmentation; white fat cell differentiation; epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of histone acetylation; negative regulation of cell adhesion mediated by integrin; regulation of chemokine production; positive regulation of cell migration

Disease: Waardenburg Syndrome, Type 2d; Piebald Trait