SARM Blocking Peptide | SARM1 blocking peptide

SARM Peptide

Cat. Num. AAA152890

• Gene Names: SARM1; SARM; SAMD2; MyD88-5
• Applications: Blocking (BL)
• Synonyms: SARM; SARM Peptide; SAMD2; MyD88-5; KIAA0524; Sterile alpha and TIR motif-containing protein 1; Sterile alpha and Armadillo repeat protein; sterile alpha and TIR motif containing 1; SARM1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 724

• Applicable Applications for SARM1 blocking peptide: Blocking (BL)
• Application Notes: SARM peptide is used for blocking the activity of SARM antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acid peptide near the amino terminus of human SARM.
• Preparation and Storage: Store SARM peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 154090976
• NCBI GeneID: 23098
• NCBI Accession #: NP_055892
• NCBI GenBank Nucleotide #: NM_015077.3
• UniProt Accession #: Q6SZW1; O60277; Q7LGG3; Q9NXY5
• Molecular Weight: 75,337 Da
• NCBI Official Full Name: sterile alpha and TIR motif-containing protein 1
• NCBI Official Synonym Full Names: sterile alpha and TIR motif containing 1
• NCBI Official Symbol: SARM1
• NCBI Official Synonym Symbols: SARM; SAMD2; MyD88-5
• NCBI Protein Information: sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
• UniProt Protein Name: Sterile alpha and TIR motif-containing protein 1
• Protein Family: Sterile alpha and TIR motif-containing protein
• UniProt Gene Name: SARM1
• UniProt Synonym Gene Names: KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2
• UniProt Entry Name: SARM1_HUMAN

Uniprot Description

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction

Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; toll-like receptor signaling pathway; response to glucose stimulus; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway