JMJD5 blocking peptide

JMJD5 Peptide

Cat. Num. AAA152843

• Gene Names: KDM8; JMJD5
• Applications: Blocking (BL)
• Synonyms: JMJD5; JMJD5 Peptide; Lysine-specific demethylase 8; JmjC domain-containing protein 5; jumonji domain containing 5; JMJD5 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 454

• Applicable Applications for JMJD5 blocking peptide: Blocking (BL)
• Application Notes: JMJD5 peptide is used for blocking the activity of JMJD5 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the carboxy terminus of human JMJD5.
• Preparation and Storage: Store JMJD5 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 223942018
• NCBI GeneID: 79831
• NCBI Accession #: NP_001138820
• NCBI GenBank Nucleotide #: NM_001145348.1
• UniProt Accession #: Q8N371; Q6VAK5; Q9H8B1; B4DLU9
• Molecular Weight: 50,852 Da
• NCBI Official Full Name: lysine-specific demethylase 8 isoform 1
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 8
• NCBI Official Symbol: KDM8
• NCBI Official Synonym Symbols: JMJD5
• NCBI Protein Information: lysine-specific demethylase 8; jumonji domain containing 5; jmjC domain-containing protein 5; jumonji domain-containing protein 5
• UniProt Protein Name: Lysine-specific demethylase 8
• UniProt Gene Name: KDM8
• UniProt Synonym Gene Names: JMJD5
• UniProt Entry Name: KDM8_HUMAN

NCBI Description

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

Uniprot Description

JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.27; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: nucleus

Molecular Function: metal ion binding; histone demethylase activity (H3-K36 specific); chromatin binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle