TRIAD3A Blocking Peptide | RNF216 blocking peptide

TRIAD3A Peptide

Cat. Num. AAA151923

• Gene Names: RNF216; ZIN; CAHH; U7I1; TRIAD3; UBCE7IP1
• Applications: Blocking (BL)
• Synonyms: TRIAD3A; TRIAD3A Peptide; ZIN; CAHH; U7I1; TRIAD3; UBCE7IP1; E3 ubiquitin-protein ligase RNF216; RING finger protein 216; ring finger protein 216; RNF216 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 866

• Applicable Applications for RNF216 blocking peptide: Blocking (BL)
• Application Notes: TRIAD3A peptide is used for blocking the activity of the TRIAD3A antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 15 amino acids near the amino terminus of human TRIAD3A.
• Preparation and Storage: Store TRIAD3A peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 31324099
• NCBI GeneID: 54476
• UniProt Accession #: Q9NWF9; Q6Y691; Q75ML7; Q7Z2H7; Q7Z7C1; Q8NHW7; Q9NYT1
• Molecular Weight: 56,697 Da
• NCBI Official Full Name: E3 ubiquitin ligase
• NCBI Official Synonym Full Names: ring finger protein 216
• NCBI Official Symbol: RNF216
• NCBI Official Synonym Symbols: ZIN; CAHH; U7I1; TRIAD3; UBCE7IP1
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF216; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF216
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF216
• UniProt Synonym Gene Names: TRIAD3; UBCE7IP1; ZIN
• UniProt Entry Name: RN216_HUMAN

NCBI Description

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]

Uniprot Description

TRIAD3: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 7p22.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; viral reproduction; apoptosis; regulation of interferon-beta production; regulation of defense response to virus by host

Disease: Gordon Holmes Syndrome