Rabbit SIPA1 Polyclonal Antibody | anti-SIPA1 antibody

SIPA1 Rabbit Polyclonal

Cat. Num. AAA7604105

• Gene Names: SIPA1; SPA1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SIPA1; Polyclonal Antibody; SIPA1 Rabbit Polyclonal; anti-SIPA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1042

• Applicable Applications for anti-SIPA1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Signal-induced proliferation-associated 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(Raji cells were subjected to SDS PAGE followed by western blot with MBS7604105 (SIPA1 antibody) at dilution of 1:3000)

NCBI and Uniprot Product Information

• NCBI GI #: 206725523
• NCBI GeneID: 6494
• NCBI Accession #: NP_006738.3
• NCBI GenBank Nucleotide #: NM_006747.3
• Molecular Weight: 112,149 Da
• NCBI Official Full Name: signal-induced proliferation-associated protein 1
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1
• NCBI Official Symbol: SIPA1
• NCBI Official Synonym Symbols: SPA1
• NCBI Protein Information: signal-induced proliferation-associated protein 1
• UniProt Protein Name: Signal-induced proliferation-associated protein 1
• Protein Family: Signal-induced proliferation-associated protein
• UniProt Gene Name: SIPA1
• UniProt Synonym Gene Names: SPA1; Sipa-1
• UniProt Entry Name: SIPA1_HUMAN

NCBI Description

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Uniprot Description

SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytosol; membrane; nucleus; perinuclear region of cytoplasm; protein complex; transport vesicle

Molecular Function: GTPase activator activity; protein binding; protein C-terminus binding

Biological Process: cell proliferation; cellular response to water deprivation; cytoskeleton organization and biogenesis; negative regulation of cell adhesion; negative regulation of cell cycle; negative regulation of cell growth; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction