Rabbit Grik3 Polyclonal Antibody | anti-GRIK3 antibody

Grik3 Antibody

Cat. Num. AAA151389

• Gene Names: GRIK3; EAA5; GLR7; GLUR7; GluK3; GluR7a
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Grik3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Grik3; Polyclonal Antibody; Grik3 Antibody; EAA5; GLR7; GLUR7; GluK3; GluR7a; Glutamate receptor ionotropic; kainate 3; Excitatory amino acid receptor 5; glutamate receptor; ionotropic; anti-GRIK3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Grik3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 872

• Applicable Applications for anti-GRIK3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Grik3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human Grik3.
• Buffer: Grik3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Grik3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-GRIK3 antibody

Grik3 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.

NCBI and Uniprot Product Information

• NCBI GI #: 56205347
• NCBI GeneID: 2899
• UniProt Accession #: Q13003; Q13004; Q16136; A9Z1Z8; B1AMS6
• Molecular Weight: 98,727 Da
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, kainate 3
• NCBI Official Symbol: GRIK3
• NCBI Official Synonym Symbols: EAA5; GLR7; GLUR7; GluK3; GluR7a
• NCBI Protein Information: glutamate receptor ionotropic, kainate 3
• UniProt Protein Name: Glutamate receptor ionotropic, kainate 3
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIK3
• UniProt Synonym Gene Names: GLUR7; GluK3; EAA5; GluR-7; GluR7
• UniProt Entry Name: GRIK3_HUMAN

NCBI Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

Uniprot Description

GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.

Protein type: Receptor, misc.; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: dendrite cytoplasm; presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; axon; dendrite; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; regulation of membrane potential; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway