Rabbit Grik3 Polyclonal Antibody | anti-Grik3 antibody

Grik3 Antibody

Cat. Num. AAA9408090

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Grik3; Polyclonal Antibody; Grik3 Antibody; Glutamate receptor ionotropic kainate 3; glutamate receptor 7; gluR7; excitatory amino acid receptor 5; eea5; anti-Grik3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 872

• Applicable Applications for anti-Grik3 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 13 amino acid peptide near the amino terminus of the human Grik3.
• Target Name: Grik3
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-Grik3 antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.

Product Categories/Family for anti-Grik3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 56205347
• UniProt Accession #: Q13003; Q13004; Q16136; A9Z1Z8; B1AMS6
• Molecular Weight: 98,727 Da
• UniProt Protein Name: Glutamate receptor ionotropic, kainate 3
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIK3
• UniProt Synonym Gene Names: GLUR7; GluK3; EAA5; GluR-7; GluR7
• UniProt Entry Name: GRIK3_HUMAN

Uniprot Description

GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: dendrite cytoplasm; presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; axon; dendrite; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; regulation of membrane potential; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway