Rabbit SLAMF2 Polyclonal Antibody | anti-CD48 antibody

SLAMF2 Antibody

Cat. Num. AAA150899

• Gene Names: CD48; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: SLAMF2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SLAMF2; Polyclonal Antibody; SLAMF2 Antibody; BCM1; BLAST; hCD48; mCD48; BLAST1; MEM-102; CD48 antigen; B-lymphocyte activation marker BLAST-1; CD48 molecule; anti-CD48 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Two isoforms of SLAMF2 are known to exist; this antibody will recognize both isoforms. SLAMF2 antibody is predicted to not cross-react with other SLAM protein family members.
• Purity/Purification: SLAMF2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 243

• Applicable Applications for anti-CD48 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: SLAMF2 antibody can be used for detection of SLAMF2 by Western blot at 1 - 2 mug/mL.
• Conjugate: Unconjugated
• Immunogen: SLAMF2 antibody was raised against a 19 amino acid synthetic peptide near the center of human SLAMF2.
• Buffer: SLAMF2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SLAMF2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SLAMF2 in rat lung tissue lysate with SLAMF2 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-CD48 antibody

SLAMF2 Antibody: The signaling lymphocyte-activation molecule family member 2 (SLAMF2), also known as CD48, is a GPI-anchored protein that exists as both a soluble and membrane-associated form and is expressed in almost all leukocyte populations particularly in mitogen-stimulated human lymphocytes. SLAMF2 is a high-affinity ligand for SLAMF4, also known as 2B4, as well as a low-affinity ligand for CD2, and can thus can stimulate cells expressing these receptors. It has been shown to be an IL-3-induced activating receptor on eosinophils and is likely to be involved in promoting allergic inflammation. SLAMF2 is also thought to be involved in the IL-18/IL-18R signaling cascade in T and natural killer cells to produce interferon-gamma.

NCBI and Uniprot Product Information

• NCBI GI #: 21361571
• NCBI GeneID: 962
• NCBI Accession #: NP_1769
• NCBI GenBank Nucleotide #: NM_001778.3
• UniProt Accession #: P09326; Q5U055; Q8MGR0
• Molecular Weight: 19,429 Da
• NCBI Official Full Name: CD48 antigen isoform 1
• NCBI Official Synonym Full Names: CD48 molecule
• NCBI Official Symbol: CD48
• NCBI Official Synonym Symbols: BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
• NCBI Protein Information: CD48 antigen; TCT.1; BCM1 surface antigen; SLAM family member 2; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); signaling lymphocytic activation molecule 2
• UniProt Protein Name: CD48 antigen
• Protein Family: CD48 antigen
• UniProt Gene Name: CD48
• UniProt Synonym Gene Names: BCM1; BLAST1; SLAMF2
• UniProt Entry Name: CD48_HUMAN

NCBI Description

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CD48: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21.3-q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: protein binding; receptor activity

Biological Process: defense response; blood coagulation; leukocyte migration