Western Blot (WB)
(Western blotAll lanes: STXBP3 antibody at 10ug/mlLane 1:HepG2 whole cell lysateLane 2:K562 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 68kDaObserved band size: 68kDa)
Rabbit anti-Human STXBP3 Polyclonal Antibody | anti-STXBP3 antibody
STXBP3 Antibody
IHC:1:20-1:200
Western Blot (WB)
(Western blotAll lanes: STXBP3 antibody at 10ug/mlLane 1:HepG2 whole cell lysateLane 2:K562 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 68kDaObserved band size: 68kDa)
Western Blot (WB)
(Western blotAll lanes: STXBP3 antibody at 10ug/mlLane 1:HepG2 whole cell lysateLane 2:K562 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 68kDaObserved band size: 68kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas tissue using MBS1495840 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas tissue using MBS1495840 at dilution 1:100)
NCBI and Uniprot Product Information
Uniprot Description
STXBP3: a vesicle protein that, together with STX4 and VAMP2, regulates the insulin-dependent movement of GLUT4 and the docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Reduction in its expression using siRNA impairs insulin-stimulated GLUT4 vesicle exocytosis in 3T3-L1 adipocytes. Phosphorylated by the insulin receptor (InsR) at Tyr521 in vitro, and bound and phosphorylated by the activated InsR within adipocytes and skeletal muscle. Tyrosine phosphorylation on residues Y219 and Y521 correlates with its dissociation from STX4. Phosphorylated by PKC in platelets in response to thrombin stimulation, inhibiting its binding to STX4. Interacts directly with DOC2B at the cell membrane, excluding its interaction with STX4, regulating glucose-stimulated insulin secretion. Belongs to the STXBP/unc-18/SEC1 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: apical plasma membrane; basolateral plasma membrane; cytosol; plasma membrane; specific granule
Molecular Function: protein binding; syntaxin binding; syntaxin-1 binding
Biological Process: blood coagulation; brain development; glucose transport; insulin secretion; negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; platelet activation; protein heterooligomerization; protein to membrane docking; response to insulin stimulus; vesicle docking during exocytosis
Research Articles on STXBP3
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Product Notes
The STXBP3 stxbp3 (Catalog #AAA1495840) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STXBP3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's STXBP3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Recommended dilution: WB:1:500-2000 IHC:1:20-1:200. Researchers should empirically determine the suitability of the STXBP3 stxbp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STXBP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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