Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1) Recombinant Protein | KAZALD1 recombinant protein

Recombinant Human Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1)

Cat. Num. AAA1477924

• Gene Names: KAZALD1; BONO1; FKSG28; FKSG40; IGFBP-rP10
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1); Recombinant Human Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1); KAZALD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 31-304, Full length protein
• Sequence: RPSPGPDYLRRGWMRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGHCGEQLECRLDTGGDLSRGEVPEPLCACRSQSPLCGSDGHTYSQICRLQEAARARPDANLTVAHPGPCESGPQIVSHPYDTWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLGRNALGQVEAPASLTVLTPDQLNSTGIPQLRSLNLVPEEEAESEENDDYY
• Sequence Length: 274

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KAZALD1 recombinant protein

This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. It contains an N-terminal insulin growth factor-binding domain, a central Kazal-type serine protease inhibitor and follistatin-like domain, and a C-terminal immunoglobulin-like domain. Studies of the mouse ortholog suggest that this gene product may have a function in bone development and bone regeneration.

NCBI and Uniprot Product Information

• NCBI GI #: 985482517
• NCBI GeneID: 81621
• NCBI Accession #: NP_001306232.1
• NCBI GenBank Nucleotide #: NM_001319303.1
• UniProt Accession #: Q96I82; Q6ZMB1; Q9BQ73; D3DR74
• Molecular Weight: 26,525 Da
• NCBI Official Full Name: kazal-type serine protease inhibitor domain-containing protein 1 isoform b
• NCBI Official Synonym Full Names: Kazal type serine peptidase inhibitor domain 1
• NCBI Official Symbol: KAZALD1
• NCBI Official Synonym Symbols: BONO1; FKSG28; FKSG40; IGFBP-rP10
• NCBI Protein Information: kazal-type serine protease inhibitor domain-containing protein 1
• UniProt Protein Name: Kazal-type serine protease inhibitor domain-containing protein 1
• Protein Family: Kazal-type serine protease inhibitor domain-containing protein
• UniProt Gene Name: KAZALD1

NCBI Description

This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. The protein contains an insulin growth factor-binding domain in its N-terminal region, a Kazal-type serine protease inhibitor and follistatin-like domain in its central region, and an immunoglobulin-like domain in its C-terminal region. Studies of the mouse ortholog suggest that this protein may function in bone development and bone regeneration. This gene is hypomethylated and over-expressed in high-grade glioma compared to low-grade glioma, and thus the hypomethylated gene may be associated with cell proliferation and the shorter survival of patients with high-grade glioma. It is also one of numerous genes found to be deleted in a novel 5.54 Mb interstitial deletion, which is associated with multiple congenital anomalies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly ().