SIX Homeobox 6 Recombinant Protein | SIX6 recombinant protein
Recombinant Human SIX Homeobox 6
Sterile Filtered colorless solution.
Introduction: SIX Homeobox 6 (SIX6) is a member of the SIX/Sine oculis homeobox family contains 1 homeobox DNA-binding domain. The SIX6 protein is essential in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. SIX6 is expressed in the developing and adult retina, hypothalamic and the pituitary regions. SIX6 gene defects are the cause of microphthalmia isolated with cataract type 2.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
Uniprot Description
SIX6: May be involved in eye development. Defects in SIX6 are the cause of microphthalmia isolated with cataract type 2 (MCOPCT2). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Belongs to the SIX/Sine oculis homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component: nucleus
Molecular Function: DNA binding
Biological Process: organ morphogenesis; visual perception; positive regulation of transcription from RNA polymerase II promoter
Disease: Microphthalmia, Isolated, With Cataract 2; Microphthalmia, Syndromic 3
Research Articles on SIX6
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Product Notes
The SIX6 six6 (Catalog #AAA146481) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMFQ LPIL NFSPQQVAGV CETLEESGDV ERLGRFLWSL PVAPAACEAL NKNESVLRAR AIVAFHGGNY RELYHILENH KFTKESHAKL QALWLEAHYQ EAEKLRGRPL GPVDKYRVRK KFPLPRTIWD GEQKTHCFKE RTRNLLREWY LQDPYPNPSK KRELAQATGL TPTQVGNWFK NRRQRDRAAA AKNRLQQQVL SQGSGRALRA EGDGTPEVLG VATSPAASLS SKAATSAISI TSSDSECDI. . It is sometimes possible for the material contained within the vial of "SIX Homeobox 6, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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