Western Blot (WB)
(Western blot analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 ug/mL.)
Rabbit Dact3 Polyclonal Antibody | anti-Dact3 antibody
Dact3 Antibody
Gene Names
DACT3; RRR1; DAPPER3
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
Dact3; Polyclonal Antibody; Dact3 Antibody; Dapper homolog 3; Dapper antagonist of beta-catenin 3; RRR3; anti-Dact3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
404
Applicable Applications for anti-Dact3 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 17 amino acid peptide from near the amino terminus of human Dact3.
Target Name
Dact3
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 ug/mL.)
Western Blot (WB)
(Western blot analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 ug/mL.)
Related Product Information for anti-Dact3 antibody
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.
Product Categories/Family for anti-Dact3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
64,949 Da
NCBI Official Full Name
dapper homolog 3 isoform 2
NCBI Official Synonym Full Names
dishevelled-binding antagonist of beta-catenin 3
NCBI Official Symbol
DACT3
NCBI Official Synonym Symbols
RRR1; DAPPER3
NCBI Protein Information
dapper homolog 3
UniProt Protein Name
Dapper homolog 3
Protein Family
UniProt Gene Name
DACT3
UniProt Synonym Gene Names
RRR1
UniProt Entry Name
DACT3_HUMAN
Uniprot Description
DACT3: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Belongs to the dapper family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm
Molecular Function: identical protein binding; protein kinase C binding; protein kinase A binding
Biological Process: Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of cell growth
Research Articles on Dact3
Similar Products
Product Notes
The Dact3 dact3 (Catalog #AAA9414279) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dact3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dact3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the Dact3 dact3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dact3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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