SRY-box 2 Recombinant Protein | Sox2-TAT recombinant protein

Recombinant Human SRY (sex determining region Y)-box 2 TAT

Cat. Num. AAA146023

• Gene Names: SOX2; ANOP3; MCOPS3
• Purity: Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
• Synonyms: SRY-box 2; Recombinant Human SRY (sex determining region Y)-box 2 TAT; SOX2 Human; TAT; SRY (sex determining region Y)-box 2 Human Recombinant; MCOPS3; ANOP3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; Sox2-TAT recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered concentrated solution in 2xPBS, pH 7.4 and 5% trehalose.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHMGGYGRKKRRQRRR
• Sequence Length: 317

• Solubility: It is recommended to reconstitute the lyophilized Sox2 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized Sox2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Sox2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for Sox2-TAT recombinant protein

Description: Sox2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (317 aa residues of the full length Sox2) and having a molecular mass of 36kDa.Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.

Introduction: SOX2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX4 is important for early embryogenesis and for embryonic stem cell pluripotency.

Product Categories/Family for Sox2-TAT recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; SRY (Sex Determining Region Y) -Box

NCBI and Uniprot Product Information

• NCBI GI #: 28195386
• NCBI GeneID: 6657
• NCBI Accession #: NP_003097.1
• NCBI GenBank Nucleotide #: NM_003106.3
• UniProt Accession #: P48431; Q14537
• Molecular Weight: 34,310 Da
• NCBI Official Full Name: transcription factor SOX-2
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 2
• NCBI Official Symbol: SOX2
• NCBI Official Synonym Symbols: ANOP3; MCOPS3
• NCBI Protein Information: transcription factor SOX-2; SRY-related HMG-box gene 2; transcription factor SOX2
• UniProt Protein Name: Transcription factor SOX-2
• UniProt Gene Name: SOX2
• UniProt Entry Name: SOX2_HUMAN

NCBI Description

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Uniprot Description

SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

Protein type: Transcription factor; Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 3q26.3-q27

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; endodermal cell fate specification; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; forebrain neuron differentiation; olfactory placode formation; detection of mechanical stimulus involved in equilibrioception; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; tissue regeneration; forebrain development; male genitalia development; response to wounding; positive regulation of cell-cell adhesion; positive regulation of epithelial cell differentiation; adenohypophysis development; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; pituitary gland development; regulation of gene expression; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; pigment biosynthetic process; alveolus development; retina morphogenesis in camera-type eye

Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia