BCL2 Like 10 Recombinant Protein | BCL2L10 recombinant protein

Recombinant Human BCL2 Like 10

Cat. Num. AAA145995

• Gene Names: BCL2L10; Boo; Diva; BCL-B
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: BCL2 Like 10; Recombinant Human BCL2 Like 10; BCL2L10 Human; BCL2 Like 10 Human Recombinant; Bcl-2-like protein 10; Bcl2-L-10; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B; BCL2L10; BCLB; Boo; Diva; BCL-B; BCL2L10 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: BCL2L10 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMVDQLRE RTTMADPLRE RTELLLADYL GYCAREPGTP EPAPSTPEAA VLRSAAARLR QIHRSFFSAY LGYPGNRFEL VALMADSVLS DSPGPTWGRV VTLVTFAGTL LERGPLVTAR WKKWGFQPRL KEQEGDVARD CQRLVALLSS RLMGQHRAWL QAQGGWDGFC HFFRT.
• Sequence Length: 204

Related Product Information for BCL2L10 recombinant protein

Description: BCL2L10 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-172 a.a.) and having a molecular mass of 21.8kDa.BCL2L10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: BCL2 Like 10 (BCL2L10) is a member of the BCL-2 protein family. BCL2 family members form hetero or homodimers and serve as anti or pro-apoptotic regulators which are involved in a wide variety of cellular activities. BCL2L10 includes the conserved BH4, BH1 and BH2 domains. BCL2L10 interacts with other members of BCL2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. BCL2L10 overexpression suppresses cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and consequently activating caspase-3 activation.

Product Categories/Family for BCL2L10 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; B Cell Lymphoma

NCBI and Uniprot Product Information

• NCBI GI #: 9966783
• NCBI GeneID: 10017
• NCBI Accession #: NP_065129.1
• NCBI GenBank Nucleotide #: NM_020396.2
• UniProt Accession #: Q9HD36; Q3SX80; Q52LQ9; Q8TCS9
• Molecular Weight: 21,973 Da
• NCBI Official Full Name: bcl-2-like protein 10
• NCBI Official Synonym Full Names: BCL2-like 10 (apoptosis facilitator)
• NCBI Official Symbol: BCL2L10
• NCBI Official Synonym Symbols: Boo; Diva; BCL-B
• NCBI Protein Information: bcl-2-like protein 10; anti-apoptotic protein NrH; apoptosis regulator Bcl-B; bcl2-L-10
• UniProt Protein Name: Bcl-2-like protein 10
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: BCL2L10
• UniProt Synonym Gene Names: BCLB; Bcl2-L-10
• UniProt Entry Name: B2L10_HUMAN

NCBI Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: mitochondrial outer membrane; nuclear membrane; mitochondrion; membrane; integral to membrane; cytosol

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis