BCL2L10 recombinant protein

BCL2L10, 1-172aa, Human, His tag, E Coli

Cat. Num. AAA204939

• Gene Names: BCL2L10; Boo; Diva; BCL-B; bcl2-L-10
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: BCL2L10; 1-172aa; Human; His tag; E Coli; Bcl-2-like protein 10; BCL-B; Boo; Diva; BCL2L10 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMVDQLRE RTTMADPLRE RTELLLADYL GYCAREPGTP EPAPSTPEAA VLRSAAARLR QIHRSFFSAY LGYPGNRFEL VALMADSVLS DSPGPTWGRV VTLVTFAGTL LERGPLVTAR WKKWGFQPRL KEQEGDVARD CQRLVALLSS RLMGQHRAWL QAQGGWDGFC HFFRT
• Sequence Length: 204

• Applicable Applications for BCL2L10 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for BCL2L10 recombinant protein

BCL2L10 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L10 contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X (L), and BAX. Overexpression of this protein has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. Recombinant human BCL2L10 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for BCL2L10 recombinant protein

Cancer

References

Kang Y, Lee DC, et al. (2007). Biochem Biophys Res Commun. 359 (1):76-82.; Guillemin Y, Lalle P, et al. (2009). J Mol Med (Berl). 87 (9):923-40.;

NCBI and Uniprot Product Information

• NCBI GI #: 9966783
• NCBI GeneID: 10017
• NCBI Accession #: NP_065129
• NCBI GenBank Nucleotide #: NM_020396.3
• UniProt Accession #: Q9HD36; Q3SX80; Q52LQ9; Q8TCS9
• Molecular Weight: 21.8 kDa (195aa), confirmed by MALDI-TOF
• NCBI Official Full Name: bcl-2-like protein 10 isoform 2
• NCBI Official Synonym Full Names: BCL2 like 10
• NCBI Official Symbol: BCL2L10
• NCBI Official Synonym Symbols: Boo; Diva; BCL-B; bcl2-L-10
• NCBI Protein Information: bcl-2-like protein 10
• UniProt Protein Name: Bcl-2-like protein 10
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: BCL2L10
• UniProt Synonym Gene Names: BCLB; Bcl2-L-10

NCBI Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.