NADH Dehydrogenase 1 Alpha Subcomplex Recombinant Protein | NDUFAF1 recombinant protein
Recombinant Human NADH Dehydrogenase 1 Alpha Subcomplex, Assembly Factor 1
Sterile Filtered colorless solution.
Introduction: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4) is involved in the compilation of mitochondrial NADH: ubiquinone oxidoreductase complex (complex I). In addition, NDUFAF4 is involved in cell proliferation and survival of hormone-dependent tumor cells. NDUFAF4 may also be a regulator of breast tumor cell invasion. NDUFAF4 gene mutations cause the mitochondrial complex I deficiency.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011]
Uniprot Description
NDUFAF1: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Belongs to the CIA30 family.
Chromosomal Location of Human Ortholog: 15q11.2-q21.3
Cellular Component: cytoplasm; mitochondrial respiratory chain complex I
Molecular Function: protein binding; unfolded protein binding
Biological Process: mitochondrial electron transport, NADH to ubiquinone; protein complex assembly
Disease: Mitochondrial Complex I Deficiency
Research Articles on NDUFAF1
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Product Notes
The NDUFAF1 ndufaf1 (Catalog #AAA145926) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMAA AAAS RGVGAKLGLR EIRIHLCQRS PGSQGVRDFI EKRYVELKKA NPDLPILIRE CSDVQPKLWA RYAFGQETNV PLNNFSADQV TRALENVLSG KA.. It is sometimes possible for the material contained within the vial of "NADH Dehydrogenase 1 Alpha Subcomplex, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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