Acyl-CoA Thioesterase 7 Recombinant Protein | ACOT7 recombinant protein

Recombinant Human Acyl-CoA Thioesterase 7

Cat. Num. AAA144376

• Gene Names: ACOT7; ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Acyl-CoA Thioesterase 7; Recombinant Human Acyl-CoA Thioesterase 7; ACOT7 Human; Acyl-CoA Thioesterase 7 Human Recombinant; Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase; ACOT7; ACT; ACH1; LACH; LACH1; hBACH; RP1-120G22.10; ACOT7 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The ACOT7 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MARPGLIHSA PGLPDTCALL QPPAASAAAA PSMSGPDVET PSAIQICRIM RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE GKGRYLQMKA KRQGHAEPQP
• Sequence Length: 370

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for ACOT7 recombinant protein

Description: ACOT7 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 390 amino acids (1-370) and having a molecular mass of 42.6kDa.ACOT7 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Acyl-CoA Thioesterase 7 (ACOT7) belongs to the acyl coenzyme family. ACOT7 hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of the ACOT7 protein may be linked to mesial temporal lobe epilepsy.

Product Categories/Family for ACOT7 recombinant protein

Enzymes; Esterase

NCBI and Uniprot Product Information

• NCBI GI #: 75709208
• NCBI GeneID: 11332
• NCBI Accession #: NP_009205.3
• NCBI GenBank Nucleotide #: NM_007274.3
• UniProt Accession #: O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12
• Molecular Weight: 40,455 Da
• NCBI Official Full Name: cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
• NCBI Official Synonym Full Names: acyl-CoA thioesterase 7
• NCBI Official Symbol: ACOT7
• NCBI Official Synonym Symbols: ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II
• NCBI Protein Information: cytosolic acyl coenzyme A thioester hydrolase; CTE-IIa; acyl-CoA thioesterase 2; acyl-CoA thioesterase, long chain; brain acyl CoA hydrolase; brain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase
• UniProt Protein Name: Cytosolic acyl coenzyme A thioester hydrolase
• Protein Family: Cytosolic acyl coenzyme A thioester hydrolase
• UniProt Gene Name: ACOT7
• UniProt Synonym Gene Names: BACH; BACH; CTE-II
• UniProt Entry Name: BACH_HUMAN

NCBI Description

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ACOT7: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.2; Lipid Metabolism - unsaturated fatty acid biosynthesis; Hydrolase

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; neuron projection; mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; protein homodimerization activity; acyl-CoA binding; palmitoyl-CoA hydrolase activity

Biological Process: medium-chain fatty acid biosynthetic process; coenzyme A biosynthetic process; fatty acid catabolic process