Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (ACOT7 Antibody) at dilution 1/30. (Original magnification: x200))
Rabbit anti-Human ACOT7 Polyclonal Antibody | anti-ACOT7 antibody
ACOT7 Antibody
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (ACOT7 Antibody) at dilution 1/30. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (ACOT7 Antibody) at dilution 1/30. (Original magnification: x200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
ACER1: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. Belongs to the alkaline ceramidase family.
Protein type: Membrane protein, integral; Hydrolase; Lipid Metabolism - sphingolipid; Endoplasmic reticulum; Membrane protein, multi-pass; EC 3.5.1.23
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: ceramidase activity
Biological Process: keratinocyte differentiation; epidermis development; regulation of lipid metabolic process; sphingolipid metabolic process; response to alkalinity; sphingolipid biosynthetic process; sphingosine biosynthetic process; ceramide catabolic process; cell differentiation
Research Articles on ACOT7
Similar Products
Product Notes
The ACOT7 acer1 (Catalog #AAA9434639) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACOT7 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ACOT7 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:30-1:150. Researchers should empirically determine the suitability of the ACOT7 acer1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACOT7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
