Monocyte Chemotactic Protein-2 Active Protein | mMCP-2 active protein
Recombinant Mouse Monocyte Chemotactic Protein-2 (CCL8)
Gene Names
Ccl8; HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Synonyms
Monocyte Chemotactic Protein-2; Recombinant Mouse Monocyte Chemotactic Protein-2 (CCL8); MCP 2 Mouse; Monocyte Chemotactic Protein-2 Mouse Recombinant (CCL8); Small inducible cytokine A8; CCL8; Monocyte chemotactic protein 2; MCP-2; Monocyte chemoattractant protein 2; HC14; chemokine (C-C motif) ligand 8; MCP2; SCYA8; SCYA10; AB023418; 1810063B20Rik; mMCP-2 active protein
Host
E Coli
Purity/Purification
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP
Sequence Length
97
Solubility
It is recommended to reconstitute the lyophilized CCL8in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Preparation and Storage
Lyophilized MCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for mMCP-2 active protein
Description: Monocyte Chemotactic Protein-2 Mouse Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8507 Dalton. The MCP-2 is purified by proprietary chromatographic techniques.
Introduction: Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.
Introduction: Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.
Product Categories/Family for mMCP-2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
11,017 Da
NCBI Official Full Name
C-C motif chemokine 8
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 8
NCBI Official Symbol
Ccl8
NCBI Official Synonym Symbols
HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik
NCBI Protein Information
C-C motif chemokine 8; monocyte chemoattractant protein 2; monocyte chemoattractant protein-2; monocyte chemotactic protein 2; small inducible cytokine A8; small-inducible cytokine A8
UniProt Protein Name
C-C motif chemokine 8
UniProt Gene Name
Ccl8
UniProt Synonym Gene Names
Mcp2; Scya8; MCP-2
UniProt Entry Name
CCL8_MOUSE
Uniprot Description
CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; chemokine activity; cytokine activity
Biological Process: immune response; chemotaxis; inflammatory response; positive regulation of myoblast differentiation
Research Articles on mMCP-2
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Product Notes
The mMCP-2 ccl8 (Catalog #AAA143826) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP. It is sometimes possible for the material contained within the vial of "Monocyte Chemotactic Protein-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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