Polycomb group RING finger protein 6 (PCGF6) Recombinant Protein | PCGF6 recombinant protein

Recombinant Human Polycomb group RING finger protein 6 (PCGF6)

Cat. Num. AAA1435240

• Gene Names: PCGF6; MBLR; RNF134
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polycomb group RING finger protein 6 (PCGF6); Recombinant Human Polycomb group RING finger protein 6 (PCGF6); PCGF6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-350, Full length protein
• Sequence: MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
• Sequence Length: 350

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PCGF6 recombinant protein

This protein contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110
MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 58761530
• NCBI GeneID: 84108
• NCBI Accession #: NP_001011663.1
• NCBI GenBank Nucleotide #: NM_001011663.1
• UniProt Accession #: Q9BYE7; Q5SYD1; Q5SYD6; Q96ID9; Q96SJ1; A8K3R4
• Molecular Weight: 30,249 Da
• NCBI Official Full Name: polycomb group RING finger protein 6 isoform a
• NCBI Official Synonym Full Names: polycomb group ring finger 6
• NCBI Official Symbol: PCGF6
• NCBI Official Synonym Symbols: MBLR; RNF134
• NCBI Protein Information: polycomb group RING finger protein 6
• UniProt Protein Name: Polycomb group RING finger protein 6
• Protein Family: Polycomb group RING finger protein
• UniProt Gene Name: PCGF6
• UniProt Synonym Gene Names: MBLR; RNF134

NCBI Description

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).