Western Blot (WB)
(Western Blot analysis of PCGF6 in MCF7 cell lysate using PCGF6 Rabbit pAb at dilution 1/1150)
Rabbit PCGF6 Polyclonal Antibody | anti-PCGF6 antibody
PCGF6 Rabbit pAb
Western Blot (WB)
(Western Blot analysis of PCGF6 in MCF7 cell lysate using PCGF6 Rabbit pAb at dilution 1/1150)
Western Blot (WB)
(Western Blot analysis of PCGF6 in MCF7 cell lysate using PCGF6 Rabbit pAb at dilution 1/1150)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
MBLR: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10q24.33
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Molecular Function: DNA binding; DNA binding transcription factor activity; metal ion binding; protein binding
Biological Process: negative regulation of G0 to G1 transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on PCGF6
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Product Notes
The PCGF6 pcgf6 (Catalog #AAA4760138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PCGF6 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PCGF6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000-1:5000. Researchers should empirically determine the suitability of the PCGF6 pcgf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCGF6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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