Thyroid hormone receptor-associated protein 3 (Thrap3) Recombinant Protein | Thrap3 recombinant protein
Recombinant Mouse Thyroid hormone receptor-associated protein 3 (Thrap3) , partial
NCBI and Uniprot Product Information
Uniprot Description
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Research Articles on Thrap3
Similar Products
Product Notes
The Thrap3 thrap3 (Catalog #AAA1434715) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 359-951; Required for mRNA decay activity. The amino acid sequence is listed below: DKEQKQTNAD KEKLKEKGGF SDADVKMKSD PFAPKTDSEK PFRGSQSPKR YKLRDDFEKK MADFHKEELD EHDKDKSKGR KEPEFDDEPK FMSKVIAGAS KNQEEEKSGK WESLHTGKEK QRKAEEMEDE PFTERSRKEE RGGSKRSESG HRGFVPEKNF RVTAYKAVQE KSSSPPPRKT SESRDKLGSK GDFSSGKSSF SITREAQVNV RMDSFDEDLA RPSGLLAQER KLCRDLVHSN KKEQEFRSIF QHIQSAQSQR SPSELFAQHI VTIVHHVKEH HFGSSGMTLH ERFTKYLKRG NEQEAAKNKK SPEIHRRIDI SPSTFRKHGL THEELKSPRE PGYKAEGKYK DDPVDLRLDI ERRKKHKERD LKRGKSRESV DSRDSSHSRE RSTEKTEKTH KGSKKQKKHR RARDRSRSSS SSSQSSHSYK AEEYPEEAEE REESTSGFDK SRLGTKDFVG PNERGGRARG TFQFRARGRG WGRGNYSGNN NNNSNNDFQK RSREEEWDPE YTPKSKKYYL HDDREGEGSD KWMGRGRGRG AFPRGRGRFM FRKSSTSPKW AHDKFSGEEG EIEDDESGTE NREEKDSLQP SAE . It is sometimes possible for the material contained within the vial of "Thyroid hormone receptor-associated protein 3 (Thrap3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
