Angiotensin Converting Enzyme 2 Active Protein | ACE2 active protein
Recombinant Human Angiotensin Converting Enzyme 2 (18-615 a.a.)
Gene Names
ACE2; ACEH
Purity
Protein is >95% pure as determined SDS-PAGE.
Synonyms
Angiotensin Converting Enzyme 2; Recombinant Human Angiotensin Converting Enzyme 2 (18-615 a.a.); ACE2 (18-615); ACE2 (18-615) Human; Angiotensin Converting Enzyme 2 (18-615 a.a.); Human Recombinan; ACE2 active protein
Host
CHO cells
Purity/Purification
Protein is >95% pure as determined SDS-PAGE.
Form/Format
Sterile filtered clear solution.
Sterile filtered clear solution.
Sterile filtered clear solution.
Sequence Positions
18-615aa
Biological Activity
ACE2 activity was measured by its binding ability in a functional ELISA.
The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike protein Receptor Binding Domain at 2ug per ml.
The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike protein Receptor Binding Domain at 2ug per ml.
Preparation and Storage
ACE-2 Human Recombinant Protein is shipped on ice packs.
Upon arrival, store at -20 degree C.
Upon arrival, store at -20 degree C.
Related Product Information for ACE2 active protein
ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries, lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors. ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1-9 and Ang II to create the heptapeptide Ang 1-7.
The CHO derived ACE2 Human recombinant protein contains the extracellular domain amino acids 18- 615 fused to Fc tag at C-terminal and has a molecular weight of ~130 kDa. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
The CHO derived ACE2 Human recombinant protein contains the extracellular domain amino acids 18- 615 fused to Fc tag at C-terminal and has a molecular weight of ~130 kDa. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
Product Categories/Family for ACE2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
~150 kDa
NCBI Official Full Name
Homo sapiens ACE-related carboxypeptidase ACE2 mRNA, complete cds
NCBI Official Synonym Full Names
angiotensin I converting enzyme 2
NCBI Official Symbol
ACE2
NCBI Official Synonym Symbols
ACEH
NCBI Protein Information
angiotensin-converting enzyme 2
Protein Family
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Product Notes
The ACE2 (Catalog #AAA141554) is an Active Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-615aa. It is sometimes possible for the material contained within the vial of "Angiotensin Converting Enzyme 2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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