Y Box Binding Protein 1 Recombinant Protein | YBX1 recombinant protein

Recombinant Human Y Box Binding Protein 1

Cat. Num. AAA140974

• Gene Names: YBX1; YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: Y Box Binding Protein 1; Recombinant Human Y Box Binding Protein 1; YBX1 Human; Y Box Binding Protein; NSEP1;DBPB; YB1; CCAAT-Binding Transcription Factor I Subunit A; Nuclease Sensitive Element Binding Protein; Enhancer Factor I Subunit A; Y-Box Transcription Factor; Y-Box-Binding Protein; DNA-Binding P; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; EFI-A; Major Histocompatibility Complex Class II Y Box-Binding Protein I; YBX1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: YBX1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH7.4) and 20% glycerol.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSSEAET QQPPAAPPAA PALSAADTKP GTTGSGAGSG GPGGLTSAAP AGGDKKVIAT KVLGTVKWFN VRNGYGFINR NDTKEDVFVH QTAIKKNNPR KYLRSVGDGE TVEFDVVEGE KGAEAANVTG PGGVPVQGSK YAADRNHYRR YPRRRGPPRN YQQNYQNSES GEKNEGSESA PEGQAQQRRP YRRRRFPPYY MRRPYGRRPQ YSNPPVQGEV MEGADNQGAG EQGRPVRQNM YRGYRPRFRR GPPRQRQPRE DGNEEDKENQ GDETQGQQPP QRRYRRNFNY RRRRPENPKP QDGKETKAAD PPAENSSAPE AEQGGAE.
• Sequence Length: 324

Related Product Information for YBX1 recombinant protein

Introduction: Y Box Binding Protein 1 (YBX1) is a part of the CRD-mediated complex which promotes MYC mRNA stability. YBX1 takes part in mammalian selenoprotein translation and mediates pre-mRNA alternative splicing regulation. YBX1 uses as a drug target in cancer therapy due to its ability to replicate adenovirus type 5, a commonly used vector in gene therapy.

Description: YBX1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-324a.a) and having a molecular mass of 38.3kDa. YBX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for YBX1 recombinant protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 34098946
• NCBI GeneID: 4904
• NCBI Accession #: NP_004550.2
• NCBI GenBank Nucleotide #: NM_004559.4
• UniProt Accession #: P67809; P16990; P16991; Q14972; Q15325; Q5FVF0
• Molecular Weight: 35,924 Da
• NCBI Official Full Name: nuclease-sensitive element-binding protein 1
• NCBI Official Synonym Full Names: Y-box binding protein 1
• NCBI Official Symbol: YBX1
• NCBI Official Synonym Symbols: YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1
• NCBI Protein Information: nuclease-sensitive element-binding protein 1
• UniProt Protein Name: Nuclease-sensitive element-binding protein 1
• Protein Family: Nuclease-sensitive element-binding protein
• UniProt Gene Name: YBX1
• UniProt Synonym Gene Names: NSEP1; YB1; CBF-A; DBPB; EFI-A; YB-1
• UniProt Entry Name: YBOX1_HUMAN

Uniprot Description

YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood.

Protein type: RNA processing; RNA splicing; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm; nucleus; ribonucleoprotein complex; stress granule; U12-dependent spliceosome

Molecular Function: DNA binding; double-stranded DNA binding; GTPase binding; protein binding; RNA binding; transcription factor activity

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter