Probable glutamate--tRNA ligase, mitochondrial (EARS2) Recombinant Protein | EARS2 recombinant protein
Recombinant Human Probable glutamate--tRNA ligase, mitochondrial (EARS2)
Gene Names
EARS2; MSE1; gluRS; COXPD12
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Probable glutamate--tRNA ligase; mitochondrial (EARS2); Recombinant Human Probable glutamate--tRNA ligase; EARS2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
42-523, Full length protein
Sequence
APSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAENIEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRYDNRCRNMSQEQVAQKLAKDPKPAIRFRLEQVVPAFQDLVYGWNRHEVASVEGDPVIMKSDGFPTYHLACVVDDHHMGISHVLRGSEWLVSTAKHLLLYQALGWQPPHFAHLPLLLNRDGSKLSKRQGDVFLEHFAADGFLPDSLLDIITNCGSGFAENQMGRTLPELITQFNLTQVTCHSALLDLEKLPEFNRLHLQRLVSNESQRRQLVGKLQVLVEEAFGCQLQNRDVLNPVYVERILLLRQGHICRLQDLVSPVYSYLWTRPAVGRAQLDAISEKVDVIAKRVLGLLERSSMSLTQDMLNGELKKLSEGLEGTKYSNVMKLLRMALSGQQQGPPVAEMMLALGPKEVRERIQKVVSS
Sequence Length
482
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59,989 Da
NCBI Official Full Name
probable glutamate--tRNA ligase, mitochondrial isoform 1
NCBI Official Synonym Full Names
glutamyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
EARS2
NCBI Official Synonym Symbols
MSE1; gluRS; COXPD12
NCBI Protein Information
probable glutamate--tRNA ligase, mitochondrial
UniProt Protein Name
Probable glutamate--tRNA ligase, mitochondrial
Protein Family
UniProt Gene Name
EARS2
UniProt Synonym Gene Names
KIAA1970; GluRS
NCBI Description
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Uniprot Description
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Research Articles on EARS2
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Product Notes
The EARS2 ears2 (Catalog #AAA1403115) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 42-523, Full length protein. The amino acid sequence is listed below: APSPTGFLHL GGLRTALYNY IFAKKYQGSF ILRLEDTDQT RVVPGAAENI EDMLEWAGIP PDESPRRGGP AGPYQQSQRL ELYAQATEAL LKTGAAYPCF CSPQRLELLK KEALRNHQTP RYDNRCRNMS QEQVAQKLAK DPKPAIRFRL EQVVPAFQDL VYGWNRHEVA SVEGDPVIMK SDGFPTYHLA CVVDDHHMGI SHVLRGSEWL VSTAKHLLLY QALGWQPPHF AHLPLLLNRD GSKLSKRQGD VFLEHFAADG FLPDSLLDII TNCGSGFAEN QMGRTLPELI TQFNLTQVTC HSALLDLEKL PEFNRLHLQR LVSNESQRRQ LVGKLQVLVE EAFGCQLQNR DVLNPVYVER ILLLRQGHIC RLQDLVSPVY SYLWTRPAVG RAQLDAISEK VDVIAKRVLG LLERSSMSLT QDMLNGELKK LSEGLEGTKY SNVMKLLRMA LSGQQQGPPV AEMMLALGPK EVRERIQKVV SS. It is sometimes possible for the material contained within the vial of "Probable glutamate--tRNA ligase, mitochondrial (EARS2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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