Mouse Histone-lysine N-methyltransferase NSD3 Monoclonal Antibody | anti-WHSC1L1 antibody

Mouse Anti Human Histone-lysine N-methyltransferase NSD3

Cat. Num. AAA140268

• Gene Names: WHSC1L1; NSD3; pp14328
• Applications: ELISA, Western Blot
• Purity: WHSC1L1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Histone-lysine N-methyltransferase NSD3; Monoclonal Antibody; Mouse Anti Human Histone-lysine N-methyltransferase NSD3; WHSC1L1 Antibody; Mouse Anti Human; Nuclear SET domain-containing protein 3; Wolf-Hirschhorn syndrome candidate 1-like protein 1; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; WHSC1-like protein 1; WHSC1L1; NSD3; DC28; pp14328; FLJ20353; MGC126766; MGC142029; DKFZp667H044; anti-WHSC1L1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and kappa light chain
• Clone Number: P2E9AT
• Purity/Purification: WHSC1L1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 645

• Applicable Applications for anti-WHSC1L1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WHSC1L1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 3,000. Recommended starting dilution is 1:2,000.
• Immunogen: Anti-human WHSC1L1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human WHSC1L1 amino acids 383-660 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-WHSC1L1 antibody

Introduction: WHSC1L1 gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the WHSC1L1 protein has not been determined. WHSC1L1 is highly expressed in brain, heart and skeletal muscle; however it is expressed at lower level in the liver and the lung.

Product Categories/Family for anti-WHSC1L1 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 13699813
• NCBI GeneID: 54904
• NCBI Accession #: NP_060248.2
• NCBI GenBank Nucleotide #: NM_017778.2
• Molecular Weight: 160,314 Da
• NCBI Official Full Name: histone-lysine N-methyltransferase NSD3 isoform short
• NCBI Official Synonym Full Names: Wolf-Hirschhorn syndrome candidate 1-like 1
• NCBI Official Symbol: WHSC1L1
• NCBI Official Synonym Symbols: NSD3; pp14328
• NCBI Protein Information: histone-lysine N-methyltransferase NSD3; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; WHSC1-like protein 1; nuclear SET domain-containing protein 3; protein whistle
• UniProt Protein Name: Histone-lysine N-methyltransferase NSD3
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: WHSC1L1
• UniProt Synonym Gene Names: NSD3; WHSC1-like protein 1
• UniProt Entry Name: NSD3_HUMAN

NCBI Description

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Methyltransferase; Methyltransferase, protein lysine; Histone-binding; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Oncoprotein

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function: protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; negative regulation of transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid