Diphthamide biosynthesis protein 2 Recombinant Protein | DPH2 recombinant protein
Recombinant Human Diphthamide biosynthesis protein 2
NCBI and Uniprot Product Information
NCBI Description
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Description
DPH2: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: cytosol
Molecular Function: protein binding
Biological Process: cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; post-translational protein modification