Diphthamide biosynthesis protein 2 Recombinant Protein | DPH2 recombinant protein

Recombinant Human Diphthamide biosynthesis protein 2

Cat. Num. AAA1379349

• Gene Names: DPH2; DPH2L2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Diphthamide biosynthesis protein 2; Recombinant Human Diphthamide biosynthesis protein 2; DPH2 homolog; HsDph2; Diphthamide biosynthesis protein 2 homolog-like 2; DPH2-like 2; DPH2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-489aa; Full Length
• Sequence: MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
• Sequence Length: 261

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for DPH2 recombinant protein

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Product Categories/Family for DPH2 recombinant protein

Cell Biology

References

Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.Schultz D.C., Balasara B.R., Testa J.R., Godwin A.K.Genomics 52:186-191(1998)

NCBI and Uniprot Product Information

• NCBI GI #: 88853059
• NCBI GeneID: 1802
• NCBI Accession #: NP_001034678.1
• NCBI GenBank Nucleotide #: NM_001039589.1
• UniProt Accession #: Q9BQC3; O60623; A8MVC9; B2RDE3; B4DNI8
• Molecular Weight: 68.1 kDa
• NCBI Official Full Name: diphthamide biosynthesis protein 2 isoform b
• NCBI Official Synonym Full Names: DPH2 homolog
• NCBI Official Symbol: DPH2
• NCBI Official Synonym Symbols: DPH2L2
• NCBI Protein Information: diphthamide biosynthesis protein 2
• UniProt Protein Name: Diphthamide biosynthesis protein 2
• Protein Family: Diphthamide biosynthesis protein
• UniProt Gene Name: DPH2
• UniProt Synonym Gene Names: DPH2L2; HsDph2; DPH2-like 2
• UniProt Entry Name: DPH2_HUMAN

NCBI Description

This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

DPH2: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. Belongs to the DPH1/DPH2 family. DPH2 subfamily.

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; post-translational protein modification