Typical Testing Data/Standard Curve (for reference only)
Rat Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) ELISA Kit | BCKDK elisa kit
Rat Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) ELISA Kit
No significant cross-reactivity or interference between Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) and analogues was observed.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
BCKDK: an atypical protein kinase associated with the mitochondrial matrix. Contains a HATPase_c domain, found in several ATP-binding proteins including protein histidine kinases (PHKs), PHDKs, DNA gyrase B, topoisomerases, heat shock proteins, and DNA mismatch repair proteins. Unlike PHKs, BCK dimerizes through direct interaction of two opposing nucleotide-binding domains. Phosphorylates and inactivates the E1-alpha subunit of the branched-chain ketoacid dehydrogenase (BCKDK), the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Inactivating mutations have been discovered in BCKDK in families with autism, epilepsy, and intellectual disability, a syndrome that may respond to dietary supplementation.
Protein type: Protein kinase, atypical; Mitochondrial; Kinase, protein; EC 2.7.11.4; ATYPICAL group; PDHK family
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: mitochondrial alpha-ketoglutarate dehydrogenase complex; mitochondrion
Molecular Function: protein serine/threonine kinase activity; protein binding; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; kinase activity; ATP binding
Biological Process: branched chain family amino acid catabolic process; protein amino acid phosphorylation; amino acid catabolic process; phosphorylation
Disease: Branched-chain Ketoacid Dehydrogenase Kinase Deficiency
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Product Notes
The Rat BCKDK bckdk (Catalog #AAA2021052) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2021052 ELISA Kit recognizes Rat BCKDK. It is sometimes possible for the material contained within the vial of "Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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