F-box only protein 9 (Fbxo9) Recombinant Protein | Fbxo9 recombinant protein
Recombinant Mouse F-box only protein 9 (Fbxo9)
Gene Names
Fbxo9; AA986398; 9030401P18Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
F-box only protein 9 (Fbxo9); Recombinant Mouse F-box only protein 9 (Fbxo9); Fbxo9 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-437, full length protein
Sequence
MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL
Sequence Length
437
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Fbxo9 recombinant protein
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5 terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,721 Da
NCBI Official Full Name
F-box only protein 9 isoform 2
NCBI Official Synonym Full Names
f-box protein 9
NCBI Official Symbol
Fbxo9
NCBI Official Synonym Symbols
AA986398; 9030401P18Rik
NCBI Protein Information
F-box only protein 9
UniProt Protein Name
F-box only protein 9
Protein Family
UniProt Gene Name
Fbxo9
Uniprot Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 ().
Research Articles on Fbxo9
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Product Notes
The Fbxo9 fbxo9 (Catalog #AAA1372206) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-437, full length protein. The amino acid sequence is listed below: MSAEAEEDCH SDADRVGDEG NESPAERDLQ AQLQMFRAQW MFELTPGVGS SHGETRPCRA GRSSMLKAAA DTKGRQELAK EEKARELFLQ AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGSGYIEEN EDASKMADLL SYFQQQLTLQ ESVLKLCQPE LETSQTHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV WGRSCMKLVP YASWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYM RFFPDGHVMM LTTPEEPPSI VPRLRTRNTR TDAILLGHYR LSQDADNQTK VFAVITKKKE EKPLDHKYRY FRRVPVQEAD HSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKATGETAVS AFEIDKMYTP LLFARVRSYT AFSERPL. It is sometimes possible for the material contained within the vial of "F-box only protein 9 (Fbxo9), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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