Muscle, skeletal receptor tyrosine protein kinase (Musk) Recombinant Protein | Musk recombinant protein

Recombinant Rat Muscle, skeletal receptor tyrosine protein kinase (Musk), partial

Cat. Num. AAA1361068

• Gene Names: Musk; Nsk1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Muscle; skeletal receptor tyrosine protein kinase (Musk); Recombinant Rat Muscle; partial; Musk recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-494
• Sequence: EKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSA LRENSRIAVL ESGSLRIHNV QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGMPV PTISWIENGN AVSSGSIQEN VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT VSIAEWSKSQ KESKGYCAQY RGEVCDAVLV KDSLVFFNTS YPDPEEAQEL LIHTAWNELK AVSPLCRPAA EALLCNHLFQ ECSPGVLPTP MPICREYCLA VKELFCAKEW LAMEGKTHRG LYRSGMHFLP VPECSKLPSM HQDPTACTRL PYLDYKKENI TTFPSITSSK PSVDIPNLPA STSSFAVSPA YSMT
• Sequence Length: 473

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 13592003
• NCBI GeneID: 81725
• NCBI Accession #: NP_112323.1
• NCBI GenBank Nucleotide #: NM_031061.1
• UniProt Accession #: Q62838
• Molecular Weight: 96,822 Da
• NCBI Official Full Name: muscle, skeletal receptor tyrosine protein kinase
• NCBI Official Synonym Full Names: muscle associated receptor tyrosine kinase
• NCBI Official Symbol: Musk
• NCBI Official Synonym Symbols: Nsk1
• NCBI Protein Information: muscle, skeletal receptor tyrosine protein kinase
• UniProt Protein Name: Muscle, skeletal receptor tyrosine protein kinase
• Protein Family: Muscle, skeletal receptor tyrosine protein kinase
• UniProt Gene Name: Musk
• UniProt Synonym Gene Names: MuSK; Muscle-specific kinase receptor

NCBI Description

receptor tyrosine kinase expressed in myotomes, developing muscle and localized to the neuromuscular junction in the adult; expression is induced in response to injury or immobilization [RGD, Feb 2006]

Uniprot Description

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:23326516). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.