PAI-1 (stable mutant) Active Protein | SERPINE1 active protein
Rabbit PAI-1 (stable mutant)
Gene Names
SERPINE1; PLANH1
Purity
>95% by SDS-PAGE analysis
Synonyms
PAI-1 (stable mutant); Rabbit PAI-1 (stable mutant); SERPINE1 active protein
Host
E. coli
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
2.5 mg/ml (varies by lot)
Sequence Length
402
Specific Activity
80percent active by titration with tPA
Buffer
0.05M Sodium Acetate; 0.1M NaCl; 1mM EDTA; pH 5.0
Extinction Coefficient
1
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Related Product Information for SERPINE1 active protein
This stable mutant of rabbit PAI-1 contains a single conservative mutation (Isoleucine 91 to Leucine) that yields PAI-1 with an enhanced half-life as compared to the wild type.
Product Categories/Family for SERPINE1 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
43,000
NCBI Official Full Name
plasminogen activator inhibitor 1
NCBI Official Symbol
SERPINE1
NCBI Official Synonym Symbols
PLANH1
NCBI Protein Information
plasminogen activator inhibitor 1; PAI; PAI-1; serpin E1; plasminogen activator inhibitor I; endothelial plasminogen activator inhibitor
UniProt Protein Name
Plasminogen activator inhibitor 1
Protein Family
UniProt Gene Name
SERPINE1
UniProt Synonym Gene Names
PAI1; PLANH1; PAI; PAI-1
UniProt Entry Name
PAI1_PIG
Uniprot Description
Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis
By similarity.
Subunit structure: Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the serpin family.
Research Articles on SERPINE1
Similar Products
Product Notes
The SERPINE1 serpine1 (Catalog #AAA135863) is an Active Protein produced from E. coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PAI-1 (stable mutant), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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