Coatomer subunit alpha (Copa) Recombinant Protein | Copa recombinant protein

Recombinant Mouse Coatomer subunit alpha (Copa) , partial

• Gene Names: Copa; xenin; AU040324
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Coatomer subunit alpha (Copa); Recombinant Mouse Coatomer subunit alpha (Copa); partial; Copa recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,224

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Copa recombinant protein

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 226823359
• NCBI GeneID: 12847
• NCBI Accession #: NP_034068.3
• NCBI GenBank Nucleotide #: NM_009938.4
• UniProt Accession #: Q8CIE6; E9Q075
• Molecular Weight: 138,432 Da
• NCBI Official Full Name: coatomer subunit alpha
• NCBI Official Synonym Full Names: coatomer protein complex subunit alpha
• NCBI Official Symbol: Copa
• NCBI Official Synonym Symbols: xenin; AU040324
• NCBI Protein Information: coatomer subunit alpha
• UniProt Protein Name: Coatomer subunit alpha
• Protein Family: Coatomer
• UniProt Gene Name: Copa
• UniProt Synonym Gene Names: Alpha-COP

Uniprot Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors ().