NCK-interacting protein with SH3 domain (Nckipsd) Recombinant Protein | Nckipsd recombinant protein

Recombinant Mouse NCK-interacting protein with SH3 domain (Nckipsd)

Cat. Num. AAA1337342

• Gene Names: Nckipsd; DIP1; ORF1; WISH; Wasbp; AF3P21; SPIN90; WASLBP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: NCK-interacting protein with SH3 domain (Nckipsd); Recombinant Mouse NCK-interacting protein with SH3 domain (Nckipsd); Nckipsd recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-714, Full length protein
• Sequence: MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGETGYVPPAYLHRLQGMEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGTSASSATVMTPSTSDHHLDAAVSRQPNGVCRTGFERQHSLPSSEHLGTDGALYQVPPQPRRAAPTTPPPPVKRRDREALVISGSGGRTAIPSGGSSVSSGSSASSTSMDTLYTGSSPSELGPSCSPTPPPVPRRGAHTTVSQPQPSPSKAPSPEPPTEEVAAETNSTPDDLEAQDALSPETTEEKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQATVPASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVEDGLPMDTTEQLPDLCMNLLLALNLHLTAPEQNVIMAALSRHTNVKIFSEKLLLLLNRGDDPVRIFRHEPQPPHSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDLQATLRRILTEEEASPQCQMDRMIVQEMYKEFPDLGEVPS
• Sequence Length: 714

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Nckipsd recombinant protein

This protein is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid
lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 49258190
• NCBI GeneID: 80987
• NCBI Accession #: NP_109654.2
• NCBI GenBank Nucleotide #: NM_030729.4
• UniProt Accession #: Q9ESJ4; Q3UYF3; Q68G72
• Molecular Weight: 78,572 Da
• NCBI Official Full Name: NCK-interacting protein with SH3 domain
• NCBI Official Synonym Full Names: NCK interacting protein with SH3 domain
• NCBI Official Symbol: Nckipsd
• NCBI Official Synonym Symbols: DIP1; ORF1; WISH; Wasbp; AF3P21; SPIN90; WASLBP
• NCBI Protein Information: NCK-interacting protein with SH3 domain
• UniProt Protein Name: NCK-interacting protein with SH3 domain
• Protein Family: NCK-interacting protein with SH3 domain
• UniProt Gene Name: Nckipsd
• UniProt Synonym Gene Names: Spin90; Wasbp; VIP54; WISH; N-WASP-binding protein

Uniprot Description

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) (). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomere and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion.