Centrosome-associated protein 350 (CEP350) Recombinant Protein | CEP350 recombinant protein

Recombinant Human Centrosome-associated protein 350 (CEP350) , partial

• Gene Names: CEP350; GM133; CAP350
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Centrosome-associated protein 350 (CEP350); Recombinant Human Centrosome-associated protein 350 (CEP350); partial; CEP350 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 3117

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CEP350 recombinant protein

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 171184451
• NCBI GeneID: 9857
• NCBI Accession #: NP_055625.4
• NCBI GenBank Nucleotide #: NM_014810.4
• UniProt Accession #: Q5VT06; O75068; Q8TDK3; Q8WY20
• Molecular Weight: 350,930 Da
• NCBI Official Full Name: centrosome-associated protein 350
• NCBI Official Synonym Full Names: centrosomal protein 350
• NCBI Official Symbol: CEP350
• NCBI Official Synonym Symbols: GM133; CAP350
• NCBI Protein Information: centrosome-associated protein 350
• UniProt Protein Name: Centrosome-associated protein 350
• Protein Family: Centrosome-associated protein
• UniProt Gene Name: CEP350
• UniProt Synonym Gene Names: Cep350

NCBI Description

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385).