Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) Recombinant Protein | CREB3L1 recombinant protein

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1), partial

Cat. Num. AAA1310991

• Gene Names: CREB3L1; OASIS
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1); Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1); partial; CREB3L1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-374
• Sequence: MDAVLEPFPA DRLFPGSSFL DLGDLNESDF LNNAHFPEHL DHFTENMEDF SNDLFSSFFD DPVLDEKSPL LDMELDSPTP GIQAEHSYSL SGDSAPQSPL VPIKMEDTTQ DAEHGAWALG HKLCSIMVKQ EQSPELPVDP LAAPSAMAAA AAMATTPLLG LSPLSRLPIP HQAPGEMTQL PVIKAEPLEV NQFLKVTPED LVQMPPTPPS SHGSDSDGSQ SPRSLPPSSP VRPMARSSTA ISTSPLLTAP HKLQGTSGPL LLTEEEKRTL IAEGYPIPTK LPLTKAEEKA LKRVRRKIKN KISAQESRRK KKEYVECLEK KVETFTSENN ELWKKVETLE NANRTLLQQL QKLQTLVTNK ISRPYKMAAT QTGT
• Sequence Length: 374

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 16418355
• NCBI GeneID: 90993
• NCBI Accession #: NP_443086.1
• NCBI GenBank Nucleotide #: NM_052854.3
• UniProt Accession #: Q96BA8; Q8N2D5; Q96CP0
• Molecular Weight: 47,783 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 1
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3 like 1
• NCBI Official Symbol: CREB3L1
• NCBI Official Synonym Symbols: OASIS
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 1
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 1
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L1
• UniProt Synonym Gene Names: OASIS; cAMP-responsive element-binding protein 3-like protein 1; OASIS

NCBI Description

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

Uniprot Description

Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).