B-cell lymphoma/leukemia 11A (BCL11A) Recombinant Protein | BCL11A recombinant protein

Recombinant Human B-cell lymphoma/leukemia 11A (BCL11A) , partial

• Gene Names: BCL11A; EVI9; CTIP1; DILOS; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: B-cell lymphoma/leukemia 11A (BCL11A); Recombinant Human B-cell lymphoma/leukemia 11A (BCL11A); partial; BCL11A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 142

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for BCL11A recombinant protein

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a
Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 20336307
• NCBI GeneID: 53335
• NCBI Accession #: NP_060484.2
• NCBI GenBank Nucleotide #: NM_018014.3
• UniProt Accession #: Q9H165; Q66LN6; Q86W14; Q8WU92; Q96JL6; Q9H163; Q9H164; Q9H3G9; Q9NWA7; D6W5D7
• Molecular Weight: 15,720 Da
• NCBI Official Full Name: B-cell lymphoma/leukemia 11A isoform 2
• NCBI Official Synonym Full Names: B cell CLL/lymphoma 11A
• NCBI Official Symbol: BCL11A
• NCBI Official Synonym Symbols: EVI9; CTIP1; DILOS; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL
• NCBI Protein Information: B-cell lymphoma/leukemia 11A
• UniProt Protein Name: B-cell lymphoma/leukemia 11A
• Protein Family: B-cell lymphoma/leukemia
• UniProt Gene Name: BCL11A
• UniProt Synonym Gene Names: CTIP1; EVI9; KIAA1809; ZNF856; BCL-11A; EVI-9

NCBI Description

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 ().