Protein AATF (Aatf) Recombinant Protein | Aatf recombinant protein
Recombinant Mouse Protein AATF (Aatf)
Gene Names
Aatf; Trb; Che-1; 4933415H02Rik; 5830465M17Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Protein AATF (Aatf); Recombinant Mouse Protein AATF (Aatf); Aatf recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-526, Full length protein
Sequence
AAPQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEKDDLAVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWEQALPSSSDNEASDEGGSEDGDSEGLGLEEISEDVDEDLEDNKISDEGGSEDGDSEGLGLEEFSEDVEEDLEGEDEEDREEDRNSEDDGVVAAFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRHIVNGAKPNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHIMMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPETLPQGPANAHLRDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTELFRSLFGQLNPPDADRGK
Sequence Length
525
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Aatf recombinant protein
This protein was identified on the basis of its interaction with MAP3K12
DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,506 Da
NCBI Official Full Name
protein AATF
NCBI Official Synonym Full Names
apoptosis antagonizing transcription factor
NCBI Official Symbol
Aatf
NCBI Official Synonym Symbols
Trb; Che-1; 4933415H02Rik; 5830465M17Rik
NCBI Protein Information
protein AATF
UniProt Protein Name
Protein AATF
Protein Family
UniProt Gene Name
Aatf
UniProt Synonym Gene Names
Che1; Trb
Uniprot Description
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression ().
Research Articles on Aatf
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Product Notes
The Aatf aatf (Catalog #AAA1286723) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-526, Full length protein. The amino acid sequence is listed below: AAPQPLALQL EQLLNPRPRE ADPEADPEEA TRARVIDRFD EGEEEKDDLA VSSIRKLAPV SLLDTDKRYS GKTTSRKAWK EDHWEQALPS SSDNEASDEG GSEDGDSEGL GLEEISEDVD EDLEDNKISD EGGSEDGDSE GLGLEEFSED VEEDLEGEDE EDREEDRNSE DDGVVAAFSS VKVSEEVEKG RAVKNQIALW DQLLEGRIKL QKALLTTNQL PQPDVFPVFK DKGGPEFASA LKNSHKALKA LLRSLVDLQE ELLFQYPDTR HIVNGAKPNT ESEEISSEDD ELVGEKKKQR KAPPKRKLEM EDYPSFMAKR FADFTIYRNH TLQKWHDKTK LASGKLGKGF GAFERSILTQ IDHIMMDKER LLRRTQTKRS AYRVLGKPEP VPEPVAETLP GEPETLPQGP ANAHLRDLDE EIFDDDDFYH QLLRELIERK TSSLDPNDQV AMGRQWLAIQ KLRSKIRKKV DRKASKGRKL RFHVLSKLLS FMAPIDHTAM SDDARTELFR SLFGQLNPPD ADRGK. It is sometimes possible for the material contained within the vial of "Protein AATF (Aatf), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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