S-arrestin (SAG) Recombinant Protein | SAG recombinant protein
Recombinant Dog S-arrestin (SAG)
Gene Names
SAG; ARR; sag1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
S-arrestin (SAG); Recombinant Dog S-arrestin (SAG); SAG recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-405, Full length protein
Sequence
MAASGKTSKSASNHVIFKKISRDKSVTIYLGKRDYIDHVEQVEPVDGIVLVDPELVKGKKVYVSLTCAFRYGQEDIDVIGLSFRRDLYFSQVQVFPPVEAAGAPTKLQESLMKKLGGNTYPFLLTFPDYLPCSVMLQPAPQDMGKCCGVDFEVKAFARDSTEDEEDKVPKKSSVRLLIRKVQHAPSKMGPQPRAEAAWQFFMSDKPLHLAVSLSKEIYFHGEPITVTVTVTNNTEKTVKKIKALVEQVANVVLYSSDYYTKPVAQEETQEKVPPNSTLTTTLTLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYHIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPATAKESFQDANLVFEEFARQNLKDFAEEGKKDREAMDE
Sequence Length
405
Species
Canis familiaris (Dog) (Canis lupus familiaris)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for SAG recombinant protein
Members of arrestin
beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,177 Da
NCBI Official Full Name
S-arrestin
NCBI Official Synonym Full Names
S-antigen visual arrestin
NCBI Official Symbol
SAG
NCBI Official Synonym Symbols
ARR; sag1
NCBI Protein Information
S-arrestin
UniProt Protein Name
S-arrestin
Protein Family
UniProt Gene Name
SAG
UniProt Synonym Gene Names
ARR; SAG1; S-AG
Uniprot Description
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
Research Articles on SAG
Similar Products
Product Notes
The SAG sag (Catalog #AAA1281651) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-405, Full length protein. The amino acid sequence is listed below: MAASGKTSKS ASNHVIFKKI SRDKSVTIYL GKRDYIDHVE QVEPVDGIVL VDPELVKGKK VYVSLTCAFR YGQEDIDVIG LSFRRDLYFS QVQVFPPVEA AGAPTKLQES LMKKLGGNTY PFLLTFPDYL PCSVMLQPAP QDMGKCCGVD FEVKAFARDS TEDEEDKVPK KSSVRLLIRK VQHAPSKMGP QPRAEAAWQF FMSDKPLHLA VSLSKEIYFH GEPITVTVTV TNNTEKTVKK IKALVEQVAN VVLYSSDYYT KPVAQEETQE KVPPNSTLTT TLTLVPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YHIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPATA KESFQDANLV FEEFARQNLK DFAEEGKKDR EAMDE. It is sometimes possible for the material contained within the vial of "S-arrestin (SAG), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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