IFIH1 cdna clone
IFIH1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]
Uniprot Description
IFIH1: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA. Interacts with MAVS/IPS1. Interacts with V protein of Simian virus 5, Human parainfluenza virus 2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state. Interacts with PCBP2. Interacts with NLRC5. Interacts with PIAS2-beta. Interacts with DDX60. By interferon (IFN) and TNF. Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. Belongs to the helicase family. RLR subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; EC 3.6.4.13; Helicase
Chromosomal Location of Human Ortholog: 2q24
Cellular Component: cytosol
Molecular Function: double-stranded RNA binding; protein binding; ribonucleoprotein binding; single-stranded RNA binding; zinc ion binding
Biological Process: detection of virus; innate immune response; negative regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; response to virus
Disease: Aicardi-goutieres Syndrome 7; Singleton-merten Syndrome 1
Research Articles on IFIH1
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Product Notes
The IFIH1 ifih1 (Catalog #AAA1278837) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCGAATG GGTATTCCAC AGACGAGAAT TTCCGCTATC TCATCTCGTG CTTCAGGGCC AGGGTGAAAA TGTACATCCA GGTGGAGCCT GTGCTGGACT ACCTGACCTT TCTGCCTGCA GAGGTGAAGG AGCAGATTCA GAGGACAGTC GCCACCTCCG GGAACATGCA GGCAGTTGAA CTGCTGCTGA GCACCTTGGA GAAGGGAGTC TGGCACCTTG GTTGGACTCG GGAATTCGTG GAGGCCCTCC GGAGAACCGG CAGCCCTCTG GCCGCCCGCT ACATGAACCC TGAGCTCACG GACTTGCCCT CTCCATCGTT TGAGAACGCT CATGATGAAT ATCTCCAACT GCTGAACCTC CTTCAGCCCA CTCTGGTGGA CAAGCTTCTA GTTAGAGACG TCTTGGATAA GTGCATGGAG GAGGAACTGT TGACAATTGA AGACAGAAAC CGGATTGCTG CTGCAGAAAA CAATGGAAAT GAATCAGGTG TAAGAGAGCT ACTAAAAAGG ATTGTGCAGA AAGAAAACTG GTTCTCTGCA TTTCTGAATG TTCTTCGTCA AACAGGAAAC AATGAACTTG TCCAAGAGTT AACAGGCTCT GATTGCTCAG AAAGCAATGC AGAGATTGAG AATTTATCAC AAGTTGATGG TCCTCAAGTG GAAGAGCAAC TTCTTTCAAC CACAGTTCAG CCAAATCTGG AGAAGGAGGT CTGGGGCATG GAGAATAACT CATCAGAATC ATCTTTTGCA GATTCTTCTG TAGTTTCAGA ATCAGACACA AGTTTGGCAG AAGGAAGTGT CAGCTGCTTA GATGAAAGTC TTGGACATAA CAGCAACATG GGCAGTGATT CAGGCACCAT GGGAAGTGAT TCAGATGAAG AGAATGTGGC AGCAAGAGCA TCCCCGGAGC CAGAACTCCA GCTCAGGCCT TACCAAATGG AAGTTGCCCA GCCAGCCTTG GAAGGGAAGA ATATCATCAT CTGCCTCCCT ACAGGGAGTG GAAAAACCAG AGTGGCTGTT TACATTGCCA AGGATCACTT AGACAAGAAG AAAAAAGCAT CTGAGCCTGG AAAAGTTATA GTTCTTGTCA ATAAGGTACT GCTAGTTGAA CAGCTCTTCC GCAAGGAGTT CCAACCATTT TTGAAGAAAT GGTATCGTGT TATTGGATTA AGTGGTGATA CCCAACTGAA AATATCATTT CCAGAAGTTG TCAAGTCCTG TGATATTATT ATCAGTACAG CTCAAATCCT TGAAAACTCC CTCTTAAACT TGGAAAATGG AGAAGATGCT GGTGTTCAAT TGTCAGACTT TTCCCTCATT ATCATTGATG AATGTCATCA CACCAACAAA GAAGCAGTGT ATAATAACAT CATGAGGCAT TATTTGATGC AGAAGTTGAA AAACAATAGA CTCAAGAAAG AAAACAAACC AGTGATTCCC CTTCCTCAGA TACTGGGACT AACAGCTTCA CCTGGTGTTG GAGGGGCCAC GAAGCAAGCC AAAGCTGAAG AACACATTTT AAAACTATGT GCCAATCTTG ATGCATTTAC TATTAAAACT GTTAAAGAAA ACCTTGATCA ACTGAAAAAC CAAATACAGG AGCCATGCAA GAAGTTTGCC ATTGCAGATG CAACCAGAGA AGATCCATTT AAAGAGAAAC TTCTAGAAAT AATGACAAGG ATTCAAACTT ATTGTCAAAT GAGTCCAATG TCAGATTTTG GAACTCAACC CTATGAACAA TGGGCCATTC AAATGGAAAA AAAAGCTGCA AAAGAAGGAA ATCGCAAAGA ACGTGTTTGT GCAGAACATT TGAGGAAGTA CAATGAGGCC CTACAAATTA ATGACACAAT TCGAATGATA GATGCGTATA CTCATCTTGA AACTTTCTAT AATGAAGAGA AAGATAAGAA GTTTGCAGTC ATAGAAGATG ATAGTGATGA GGGTGGTGAT GATGAGTATT GTGATGGTGA TGAAGATGAG GATGATTTAA AGAAACCTTT GAAACTGGAT GAAACAGATA GATTTCTCAT GACTTTATTT TTTGAAAACA ATAAAATGTT GAAAAGGCTG GCTGAAAACC CAGAATATGA AAATGAAAAG CTGACCAAAT TAAGAAATAC CATAATGGAG CAATATACTA GGACTGAGGA ATCAGCACGA GGAATAATCT TTACAAAAAC ACGACAGAGT GCATATGCGC TTTCCCAGTG GATTACTGAA AATGAAAAAT TTGCTGAAGT AGGAGTCAAA GCCCACCATC TGATTGGAGC TGGACACAGC AGTGAGTTCA AACCCATGAC ACAGAATGAA CAAAAAGAAG TCATTAGTAA ATTTCGCACT GGAAAAATAA ATCTGCTTAT CGCTACCACA GTGGCAGAAG AAGGTCTGGA TATTAAAGAA TGTAACATTG TTATCCGTTA TGGTCTCGTC ACCAATGAAA TAGCCATGGT CCAGGCCCGT GGTCGAGCCA GAGCTGATGA GAGCACCTAC GTCCTGGTTG CTCACAGTGG TTCAGGAGTT ATCGAACGTG AGACAGTTAA TGATTTCCGA GAGAAGATGA TGTATAAAGC TATACATTGT GTTCAAAATA TGAAACCAGA GGAGTATGCT CATAAGATTT TGGAATTACA GATGCAAAGT ATAATGGAAA AGAAAATGAA AACCAAGAGA AATATTGCCA AGCATTACAA GAATAACCCA TCACTAATAA CTTTCCTTTG CAAAAACTGC AGTGTGCTAG CCTGTTCTGG GGAAGATATC CATGTAATTG AGAAAATGCA TCACGTCAAT ATGACCCCAG AATTCAAGGA ACTTTACATT GTAAGAGAAA ACAAAACACT GCAAAAGAAG TGTGCCGACT ATCAAATAAA TGGTGAAATC ATCTGCAAAT GTGGCCAGGC TTGGGGAACA ATGATGGTGC ACAAAGGCTT AGATTTGCCT TGTCTCAAAA TAAGGAATTT TGTAGTGGTT TTCAAAAATA ATTCAACAAA GAAACAATAC AAAAAGTGGG TAGAATTACC TATCACATTT CCCAATCTTG ACTATTCAGA ATGCTGTTTA TTTAGTGATG AGGATTAG. It is sometimes possible for the material contained within the vial of "IFIH1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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