MIB1 cdna clone
MIB1 cDNA Clone
Gene Names
MIB1; MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2
Synonyms
MIB1; MIB1 cDNA Clone; MIB1 cdna clone
Sequence
ATGAGTAACTCCCGGAATAACCGGGTGATGGTGGAAGGGGTTGGCGCTCGGGTAGTGCGCGGCCCGGACTGGAAGTGGGGGAAGCAGGACGGCGGCGAGGGCCATGTGGGCACCGTCCGGAGCTTCGAGAGCCCCGAGGAGGTGGTGGTAGTGTGGGACAACGGCACAGCTGCCAACTACCGCTGCTCCGGGGCTTACGACCTCCGCATCCTGGACAGCGCGCCCACCGGCATCAAGCATGATGGAACCATGTGTGATACCTGCCGCCAGCAACCAATCATTGGCATTCGATGGAAGTGTGCAGAGTGTACAAATTATGATTTGTGCACAGTGTGTTATCATGGAGATAAACATCATTTAAGACATCGCTTTTACCGAATTACTACACCGGGAAGTGAGAGGGTTCTGTTAGAGTCTCGTAGGAAATCTAAGAAGATTACAGCCAGAGGAATCTTTGCAGGTGCCAGAGTGGTGCGAGGAGTGGACTGGCAGTGGGAAGATCAAGATGGAGGAAATGGACGTAGGGGAAAGGTAACAGAAATCCAGGACTGGAGTGCATCAAGCCCACATAGCGCAGCATATGTCCTCTGGGATAATGGTGCTAAGAACCTTTACAGAGTTGGCTTTGAGGGCATGTCTGATCTGAAATGTGTCCAGGATGCCAAGGGAGGTTCTTTCTACAGAGATCACTGCCCTGTGCTAGGTGAGCAGAATGGCAACAGGAATCCTGGTGGATTGCAGATTGGTGACCTGGTAAATATAGATCTCGACCTCGAAATTGTACAGTCTTTGCAGCATGGTCATGGAGGATGGACTGATGGAATGTTTGAGACTTTAACTACAACTGGAACTGTTTGTGGCATTGATGAAGATCATGACATTGTAGTACAGTATCCAAGTGGCAATAGGTGGACCTTCAATCCTGCTGTTCTCACTAAAGCGAACATTGTCCGAAGTGGAGATGCTGCTCAGGGTGCAGAAGGAGGCACCTCGCAGTTTCAAGTGGGTGATCTTGTACAAGTTTGTTATGACCTGGAACGAATTAAACTTCTACAAAGAGGACATGGAGAATGGGCTGAAGCGATGCTTCCAACTTTAGGTAAAGTTGGCCGAGTACAACAGATTTATTCAGACAGTGATTTAAAGGTGGAAGTTTGTGGAACATCTTGGACATACAATCCAGCAGCAGTTTCCAAGGTGGCATCTGCAGGATCAGCCATTAGCAATGCATCTGGTGAAAGACTCTCACAACTCCTGAAGAAATTATTTGAAACCCAAGAATCTGGTGACCTCAATGAAGAATTAGTTAAGGCTGCTGCCAATGGAGATGTTGCTAAAGTGGAAGATTTGCTTAAAAGACCAGATGTGGATGTAAATGGGCAATGTGCTGGCCACACAGCTATGCAAGCTGCTAGTCAGAATGGACATGTTGACATTTTGAAGTTACTTTTGAAGCAAAACGTGGATGTCGAAGCAGAGGATAAAGATGGTGATAGAGCAGTTCACCATGCAGCTTTTGGAGATGAAGGCGCTGTTATAGAAGTACTACATCGAGGTAGTGCTGATTTGAATGCTCGAAACAAGCGCCGACAGACACCACTTCATATTGCTGTCAATAAAGGTCATCTTCAAGTTGTGAAGACTTTATTGGACTTTGGCTGTCATCCCAGTCTCCAGGATTCTGAAGGTGATACCCCTCTTCATGATGCAATAAGTAAGAAACGTGATGATATCCTAGCAGTTCTTTTGGAAGCTGGAGCAGATGTTACCATCACAAACAATAATGGATTTAATGCTCTGCATCATGCTGCACTAAGGGGAAATCCCAGTGCAATGCGTGTTTTACTATCTAAATTACCAAGACCATGGATTGTGGATGAGAAGAAAGATGATGGTTATACTGCCTTACATCTGGCTGCCCTTAATAATCACGTAGAAGTGGCTGAACTGTTGGTACATCAGGGTAATGCAAACCTGGATATCCAGAATGTGAACCAACAAACTGCCCTACACCTTGCTGTTGAACGACAGCATACCCAGATTGTTAGGCTTTTGGTCCGTGCAGGTGCCAAGCTTGATATTCAGGATAAGGATGGGGATACTCCTTTGCATGAAGCTCTAAGGCATCACACTTTGTCTCAGCTACGTCAGCTCCAAGATATGCAAGATGTGGGGAAGGTGGATGCTGCCTGGGAGCCATCCAAAAACACGTTAATAATGGGACTTGGTACCCAGGGGGCAGAGAAGAAGAGTGCAGCATCTATTGCCTGTTTCTTGGCAGCCAATGGTGCTGACCTGAGCATTCGAAATAAGAAGGGTCAATCGCCACTTGATCTCTGTCCTGATCCGAATCTCTGCAAAGCACTGGCAAAGTGTCATAAGGAAAAAGTCAGTGGTCAAGTGGGTTCTCGGAGTCCTTCTATGATTAGTAATGATTCTGAAACCTTAGAAGAGTGTATGGTGTGCTCAGATATGAAGAGAGATACTCTTTTTGGTCCATGTGGACATATTGCTACCTGTTCTTTATGTTCTCCACGTGTCAAGAAATGCCTCATCTGTAAAGAACAGGTTCAATCCAGGACAAAGATTGAAGAATGTGTGGTATGCTCTGACAAGAAAGCAGCTGTTCTTTTTCAACCCTGTGGCCACATGTGTGCTTGTGAGAACTGTGCTAACCTGATGAAAAAGTGTGTGCAGTGTCGAGCAGTAGTTGAACGAAGAGTGCCTTTCATTATGTGCTGTGGAGGGAAAAGTTCAGAAGATGCCACTGATGATATCTCAAGTGGGAATATTCCAGTATTACAAAAGGACAAGGATAATACCAATGTCAATGCAGATGTGCAAAAGTTGCAGCAACAGTTACAAGACATTAAAGAGCAGACAATGTGCCCTGTGTGTCTAGATCGTCTGAAGAATATGATTTTCCTTTGTGGTCACGGAACCTGTCAACTCTGTGGAGACCGCATGAGTGAATGTCCTATCTGTCGCAAGGCTATTGAACGAAGGATTCTTTTGTATTAA
Sequence Length
3021
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
110,136 Da
NCBI Official Full Name
Homo sapiens mindbomb homolog 1 (Drosophila), mRNA
NCBI Official Synonym Full Names
mindbomb E3 ubiquitin protein ligase 1
NCBI Official Symbol
MIB1
NCBI Official Synonym Symbols
MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2
NCBI Protein Information
E3 ubiquitin-protein ligase MIB1
UniProt Protein Name
E3 ubiquitin-protein ligase MIB1
Protein Family
UniProt Gene Name
MIB1
UniProt Synonym Gene Names
DIP1; KIAA1323; ZZANK2; DIP-1
UniProt Entry Name
MIB1_HUMAN
NCBI Description
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]
Uniprot Description
MIB1: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: centrosome; cytoplasm; cytosol
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: endocytosis; Notch signaling pathway
Disease: Left Ventricular Noncompaction 7
Research Articles on MIB1
Similar Products
Product Notes
The MIB1 mib1 (Catalog #AAA1278446) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGTAACT CCCGGAATAA CCGGGTGATG GTGGAAGGGG TTGGCGCTCG GGTAGTGCGC GGCCCGGACT GGAAGTGGGG GAAGCAGGAC GGCGGCGAGG GCCATGTGGG CACCGTCCGG AGCTTCGAGA GCCCCGAGGA GGTGGTGGTA GTGTGGGACA ACGGCACAGC TGCCAACTAC CGCTGCTCCG GGGCTTACGA CCTCCGCATC CTGGACAGCG CGCCCACCGG CATCAAGCAT GATGGAACCA TGTGTGATAC CTGCCGCCAG CAACCAATCA TTGGCATTCG ATGGAAGTGT GCAGAGTGTA CAAATTATGA TTTGTGCACA GTGTGTTATC ATGGAGATAA ACATCATTTA AGACATCGCT TTTACCGAAT TACTACACCG GGAAGTGAGA GGGTTCTGTT AGAGTCTCGT AGGAAATCTA AGAAGATTAC AGCCAGAGGA ATCTTTGCAG GTGCCAGAGT GGTGCGAGGA GTGGACTGGC AGTGGGAAGA TCAAGATGGA GGAAATGGAC GTAGGGGAAA GGTAACAGAA ATCCAGGACT GGAGTGCATC AAGCCCACAT AGCGCAGCAT ATGTCCTCTG GGATAATGGT GCTAAGAACC TTTACAGAGT TGGCTTTGAG GGCATGTCTG ATCTGAAATG TGTCCAGGAT GCCAAGGGAG GTTCTTTCTA CAGAGATCAC TGCCCTGTGC TAGGTGAGCA GAATGGCAAC AGGAATCCTG GTGGATTGCA GATTGGTGAC CTGGTAAATA TAGATCTCGA CCTCGAAATT GTACAGTCTT TGCAGCATGG TCATGGAGGA TGGACTGATG GAATGTTTGA GACTTTAACT ACAACTGGAA CTGTTTGTGG CATTGATGAA GATCATGACA TTGTAGTACA GTATCCAAGT GGCAATAGGT GGACCTTCAA TCCTGCTGTT CTCACTAAAG CGAACATTGT CCGAAGTGGA GATGCTGCTC AGGGTGCAGA AGGAGGCACC TCGCAGTTTC AAGTGGGTGA TCTTGTACAA GTTTGTTATG ACCTGGAACG AATTAAACTT CTACAAAGAG GACATGGAGA ATGGGCTGAA GCGATGCTTC CAACTTTAGG TAAAGTTGGC CGAGTACAAC AGATTTATTC AGACAGTGAT TTAAAGGTGG AAGTTTGTGG AACATCTTGG ACATACAATC CAGCAGCAGT TTCCAAGGTG GCATCTGCAG GATCAGCCAT TAGCAATGCA TCTGGTGAAA GACTCTCACA ACTCCTGAAG AAATTATTTG AAACCCAAGA ATCTGGTGAC CTCAATGAAG AATTAGTTAA GGCTGCTGCC AATGGAGATG TTGCTAAAGT GGAAGATTTG CTTAAAAGAC CAGATGTGGA TGTAAATGGG CAATGTGCTG GCCACACAGC TATGCAAGCT GCTAGTCAGA ATGGACATGT TGACATTTTG AAGTTACTTT TGAAGCAAAA CGTGGATGTC GAAGCAGAGG ATAAAGATGG TGATAGAGCA GTTCACCATG CAGCTTTTGG AGATGAAGGC GCTGTTATAG AAGTACTACA TCGAGGTAGT GCTGATTTGA ATGCTCGAAA CAAGCGCCGA CAGACACCAC TTCATATTGC TGTCAATAAA GGTCATCTTC AAGTTGTGAA GACTTTATTG GACTTTGGCT GTCATCCCAG TCTCCAGGAT TCTGAAGGTG ATACCCCTCT TCATGATGCA ATAAGTAAGA AACGTGATGA TATCCTAGCA GTTCTTTTGG AAGCTGGAGC AGATGTTACC ATCACAAACA ATAATGGATT TAATGCTCTG CATCATGCTG CACTAAGGGG AAATCCCAGT GCAATGCGTG TTTTACTATC TAAATTACCA AGACCATGGA TTGTGGATGA GAAGAAAGAT GATGGTTATA CTGCCTTACA TCTGGCTGCC CTTAATAATC ACGTAGAAGT GGCTGAACTG TTGGTACATC AGGGTAATGC AAACCTGGAT ATCCAGAATG TGAACCAACA AACTGCCCTA CACCTTGCTG TTGAACGACA GCATACCCAG ATTGTTAGGC TTTTGGTCCG TGCAGGTGCC AAGCTTGATA TTCAGGATAA GGATGGGGAT ACTCCTTTGC ATGAAGCTCT AAGGCATCAC ACTTTGTCTC AGCTACGTCA GCTCCAAGAT ATGCAAGATG TGGGGAAGGT GGATGCTGCC TGGGAGCCAT CCAAAAACAC GTTAATAATG GGACTTGGTA CCCAGGGGGC AGAGAAGAAG AGTGCAGCAT CTATTGCCTG TTTCTTGGCA GCCAATGGTG CTGACCTGAG CATTCGAAAT AAGAAGGGTC AATCGCCACT TGATCTCTGT CCTGATCCGA ATCTCTGCAA AGCACTGGCA AAGTGTCATA AGGAAAAAGT CAGTGGTCAA GTGGGTTCTC GGAGTCCTTC TATGATTAGT AATGATTCTG AAACCTTAGA AGAGTGTATG GTGTGCTCAG ATATGAAGAG AGATACTCTT TTTGGTCCAT GTGGACATAT TGCTACCTGT TCTTTATGTT CTCCACGTGT CAAGAAATGC CTCATCTGTA AAGAACAGGT TCAATCCAGG ACAAAGATTG AAGAATGTGT GGTATGCTCT GACAAGAAAG CAGCTGTTCT TTTTCAACCC TGTGGCCACA TGTGTGCTTG TGAGAACTGT GCTAACCTGA TGAAAAAGTG TGTGCAGTGT CGAGCAGTAG TTGAACGAAG AGTGCCTTTC ATTATGTGCT GTGGAGGGAA AAGTTCAGAA GATGCCACTG ATGATATCTC AAGTGGGAAT ATTCCAGTAT TACAAAAGGA CAAGGATAAT ACCAATGTCA ATGCAGATGT GCAAAAGTTG CAGCAACAGT TACAAGACAT TAAAGAGCAG ACAATGTGCC CTGTGTGTCT AGATCGTCTG AAGAATATGA TTTTCCTTTG TGGTCACGGA ACCTGTCAAC TCTGTGGAGA CCGCATGAGT GAATGTCCTA TCTGTCGCAA GGCTATTGAA CGAAGGATTC TTTTGTATTA A. It is sometimes possible for the material contained within the vial of "MIB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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