UBE2M cdna clone
UBE2M cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Uniprot Description
UBE2M: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. Interacts with UBA3, DCUN1D1 and RBX1. Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: cytoplasm; cytosol
Molecular Function: NEDD8 ligase activity; protein binding; ribosomal S6-glutamic acid ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: protein modification process; protein neddylation; transforming growth factor beta receptor signaling pathway
Research Articles on UBE2M
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Product Notes
The UBE2M ube2m (Catalog #AAA1277978) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgatcaagc tgttctcgct gaagcagcag aagaaggagg aggagtcggc gggcggcacc aagggcagca gcaagaaggc gtcggcggcg cagctgcgga tccagaagga cataaacgag ctgaacctgc ccaagacgtg tgatatcagc ttctcagatc cagacgacct cctcaacttc aagctggtca tctgtcctga tgagggcttc tacaagagtg ggaagtttgt gttcagtttt aaggtgggcc agggttaccc gcatgatccc cccaaggtga agtgtgagac aatggtctat caccccaaca ttgacctcga gggcaacgtc tgcctcaaca tcctcagaga ggactggaag ccagtcctta cgataaactc cataatttat ggcctgcagt atctcttctt ggagcccaac cccgaggacc cactgaacaa ggaggccgca gaggtcctgc agaacaaccg gcggctgttt gagcagaacg tgcagcgctc catgcggggt ggctacatcg gctccaccta ctttgagcgc tgcctgaaat ag. It is sometimes possible for the material contained within the vial of "UBE2M, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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