CCNE2 cdna clone
CCNE2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Uniprot Description
CCNE2: Essential for the control of the cell cycle at the late G1 and early S phase. Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. Belongs to the cyclin family. Cyclin E subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Activator
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: cytosol; nucleoplasm
Molecular Function: protein binding
Biological Process: cell cycle checkpoint; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein kinase activity
Research Articles on CCNE2
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Product Notes
The CCNE2 ccne2 (Catalog #AAA1277236) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcaaaag aagtctggct aaacatgtta aaaaaggaga gcagatatgt tcatgacaaa cattttgaag ttctgcattc tgacttggaa ccacagatga ggtccatact tctagactgg cttttagagg tatgtgaagt atacacactt catagggaaa cattttatct tgcacaagac ttttttgata gatttatgtt gacacaaaag gatataaata aaaatatgct tcaactcatt ggaattacct cattattcat tgcttccaaa cttgaggaaa tctatgctcc taaactccaa gagtttgctt acgtcactga tggtgcttgc agtgaagagg atatcttaag gatggaactc attatattaa aggctttaaa atgggaactt tgtcctgtaa caatcatctc ctggctaaat ctctttctcc aagttgatgc tcttaaagat gctcctaaag ttcttctacc tcagtattct caggaaacat tcattcaaat agctcagctt ttagatctgt gtattctagc cattgattca ttagagttcc agtacagaat actgactgct gctgccttgt gccattttac ctccattgaa gtggttaaga aagcctcagg tttggagtgg gacagtattt cagaatgtgt agattggatg gtaccttttg tcaatgtagt aaaaagtact agtccagtga agctgaagac ttttaagaag attcctatgg aagacagaca taatatccag acacatacaa actatttggc tatgctggag gaagtaaatt acataaacac cttcagaaaa gggggacagt tgtcaccagt gtgcaatgga ggcattatga caccaccgaa gagcactgaa aaaccaccag gaaaacacta a. It is sometimes possible for the material contained within the vial of "CCNE2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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