Immunohistochemistry (IHC)
(Immunochemical staining of human VPS35 in human duodenum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human VPS35 Polyclonal Antibody | anti-VPS35 antibody
Anti-VPS35 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
VPS35; Polyclonal Antibody; Anti-VPS35 Antibody; Rabbit Polyclonal; VPS35 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-MEM3 Antibody; Anti-PARK17 Antibody; anti-VPS35 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human VPS35
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-VPS35 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human VPS35 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human VPS35 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human VPS35 in human duodenum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human VPS35 in human duodenum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-VPS35 antibody
The vacuolar protein sorting 35 (VPS35) gene, located on chromosome 16, is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. VPS35 gene encodes a 796-residue protein nearly ubiquitously expressed in human tissues. The protein localizes on endosomes where it assembles with other peripheral membrane proteins to form the retromer complex. VPS35-deficiency is believed to increase the risk of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Mutations in VPS35 gene have been identified in patients with autosomal dominant PD or early onset AD.
References
Williams ET, et al. (2017) Vps35, the retromer complex and parkinson's disease. J Parkinsons Dis 7 (2): 219-233.Vagnozzi AN, et al. (2019) Vps35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry Sassone J, et al. (2020) The role of vps35 in the pathobiology of parkinson's disease. Cell Mol Neurobiol
Similar Products
Product Notes
The VPS35 (Catalog #AAA8108849) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-VPS35 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VPS35 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the VPS35 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS35, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
