KIR2DS2 cdna clone
KIR2DS2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
KIR2DS2: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: plasma membrane
Biological Process: innate immune response; regulation of immune response
Research Articles on KIR2DS2
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Product Notes
The KIR2DS2 kir2ds2 (Catalog #AAA1277116) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCGCTCA CTGTCGTCAG CATGGCGTGT GTTGGGTTCT TCTTGCTGCA GGGGGCCTGG CCACATGAGG GAGTCCACAG AAAACCTTCC CTCCTGGCCC ACCCAGGTCC CCTGGTGAAA TCAGAAGAGA CAGTCATCCT GCAATGTTGG TCAGATGTCA GGTTTGAGCA CTTCCTTCTG CACAGAGAGG GGAAGTATAA GGACACTTTG CACCTCATTG GAGAGCACCA TGATGGGGTC TCCAAGGCCA ACTTCTCCAT CGGTCCCATG ATGCAAGACC TTGCAGGGAC CTACAGATGC TACGGTTCTG TTACTCACTC CCCCTATCAG TTGTCAGCTC CCAGTGACCC TCTGGACATC GTCATCACAG GTCTATATGA GAAACCTTCT CTCTCAGCCC AGCCGGGCCC CACGGTTTTG GCAGGAGAGA GCGTGACCTT GTCCTGCAGC TCCCGGAGCT CCTATGACAT GTACCATCTA TCCAGGGAGG GGGAGGCCCA TGAACGTAGG TTCTCTGCAG GGCCCAAGGT CAACGGAACA TTCCAGGCCG ACTTTCCTCT GGGCCCTGCC ACCCACGGAG GAACCTACAG ATGCTTCGGC TCTTTCCGTG ACTCTCCCTA TGAGTGGTCA AACTCGAGTG ACCCACTGCT TGTTTCTGTC ACAGGAAACC CTTCAAATAG TTGGCCTTCA CCCACTGAAC CAAGCTCCAA AACCGGTAAC CCCAGACACC TGCATGTTCT GATTGGGACC TCAGTGGTCA AAATCCCTTT CACCATCCTC CTCTTCTTTC TCCTTCATCG CTGGTGCTCC AACAAAAAAA ATGCTGCTGT AATGGACCAA GAGCCTGCAG GGAACAGAAC AGTGAACAGC GAGAGAGAAA TCACTCGCCC TTCTGAGAGG CCCAAGACAC CCCCAACAGA TACCAGCATG TACATAGAAC TTCCAAATGC TGAGCCCAGA TCCAAAGTTG TCTTCTGTCC ACGAGCACCA CAGTCAGGCC TTGAGGGGAT CTTCTAG. It is sometimes possible for the material contained within the vial of "KIR2DS2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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