TRIM37 cdna clone
TRIM37 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]
Uniprot Description
TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Oncoprotein; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: cytoplasm; cytosol; ESC/E(Z) complex; peroxisome
Molecular Function: protein binding; protein homodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of centriole replication; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; protein autoubiquitination
Disease: Mulibrey Nanism
Research Articles on TRIM37
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Product Notes
The TRIM37 trim37 (Catalog #AAA1275371) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatgaac agagcgtgga gagcattgct gaggttttcc gatgtttcat ttgtatggag aaattgcggg atgcacgcct gtgtcctcat tgctccaaac tgtgttgttt cagctgtatt aggcgctggc tgacagagca gagagctcaa tgtcctcatt gccgtgctcc actccagcta cgagaactag taaattgtcg ttgggcagaa gaagtaacac aacagcttga tactcttcaa ctctgcagtc tcaccaaaca tgaagaaaat gaaaaggaca aatgtgaaaa tcaccatgaa aaacttagtg tattttgctg ggcttgtaag aagtgtatct gccatcagtg tgcactttgg ggaggaatgc atggcggaca tacctttaaa cctttggcag aaatttatga gcaacacgtc actaaagtga atgaagaggt agccaaactt cgtcggcgtc tcatggaact gatcagctta gttcaagaag tggaaaggaa tgtagaagct gtaagaaatg caaaagatga gcgtgttcgg gaaattagga atgcagtgga gatgatgatt gcacggttag acacacagct gaagaataag cttataacac tgatgggtca gaagacatct ctaacccaag aaacagagct tttggaatcc ttacttcagg aggtggagca ccagttgcgg tcttgtagta agagtgagtt gatatctaag agctcagaga tccttatgat gtttcagcaa gttcatcgga agcccatggc atcttttgtt accactcctg ttccaccaga ctttaccagt gaattagtgc catcttacga ttcagctact tttgttttag agaatttcag cactttgcgt cagagagcag atcctgttta cagtccacct cttcaagttt caggactttg ctggaggtta aaagtttacc cagatggaaa tggagttgtg cgaggttact acttatctgt gtttctggag ctctcagctg gcttgcctga aacttctaaa tatgaatatc gtgtagagat ggttcaccag tcctgtaatg atcctacaaa aaatatcatt cgagaatttg catctgactt tgaagttgga gaatgctggg gctataatag atttttccgt ttggacttac tcgcaaatga aggatacttg aatccacaaa atgatacagt gattttaagg tttcaggtac gttcaccaac tttctttcaa aaatcccggg accagcattg gtacattact cagctggaag ctgcacagac tagttatatc caacaaataa acaaccttaa agagagactt actattgagc tgtctcgaac tcagaagtca agagatttgt caccaccaga taaccatctt agcccccaaa atgatgatgc tctggagaca cgagctaaga agtctgcatg ctctgacatg cttctcgaag gtggtcctac tacagcttct gtaagagagg ccaaagagga tgaagaagat gaggagaaga ttcagaatga agattatcat cacgagcttt cagatggaga tctggatctg gatcttgttt atgaggatga agtaaatcag ctcgatggca gcagttcctc tgctagttcc acagcaacaa gtaatacaga agaaaatgat attgatgaag aaactatgtc tggagaaaat gatgtggaat ataacaacat ggaattagaa gagggagaac tcatggaaga tgcagctgct gcaggacccg caggtagtag ccatggttat gtgggttcca gtagtagaat atcaagaaga acacatttat gctccgctgc taccagtagt ttactagaca ttgatccatt aattttaata catttgttgg accttaagga ccggagcagt atagaaaatt tgtggggctt acagcctcgc ccacctgctt cacttctgca gcccacagca tcatattctc gaaaagataa agaccaaagg aagcaacagg caatgtggcg agtgccctct gatttaaaga tgctaaaaag actcaaaact caaatggccg aagttcgatg tatgaaaact gatgtaaaga atacactttc agaaataaaa agcagcagtg ctgcttctgg agacatgcag acaagccttt tttctgctga ccaggcagct ctggctgcat gtggaactga aaactctggc agattgcagg atttgggaat ggaactcctg gcaaagtcat cagttgccaa ttgttacata cgaaactcca caaataagaa gagtaattcg cccaagccag ctcgatccag tgtagcaggt agtctatcac ttcgaagagc agtggaccct ggagaaaata gtcgttcaaa gggagactgt cagactctgt ctgaaggctc cccaggaagc tctcagtctg ggagcaggca cagttctccc cgagccttga tacatggcag tatcggtgat attctgccaa aaactgaaga ccggcagtgt aaagctttgg attcagatgc tgttgtggtt gcagttttca gtggcttgcc tgcggttgag aaaaggagga aaatggtcac cttgggggct aatgctaaag gaggtcatct ggaaggactg cagatgactg atttggaaaa taattctgaa actggagagt tacagcctgt actacctgaa ggagcttcag ctgcccctga agaaggaatg agtagcgaca gtgacattga atgtgacact gagaatgagg agcaggaaga gcataccagt gtgggcgggt ttcacgactc cttcatggtc atgacacagc ccccggatga agatacacat tccagttttc ctgatggtga acaaataggc cctgaagatc tcagcttcaa tacagatgaa aatagtggaa gataa. It is sometimes possible for the material contained within the vial of "TRIM37, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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