Rabbit TRIM37 Polyclonal Antibody | anti-TRIM37 antibody

TRIM37 Rabbit Polyclonal

Cat. Num. AAA7605215

• Gene Names: TRIM37; MUL; POB1; TEF3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TRIM37; Polyclonal Antibody; TRIM37 Rabbit Polyclonal; anti-TRIM37 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 964

• Applicable Applications for anti-TRIM37 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Tripartite motif-containing 37
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(PC-3 cells were subjected to SDS PAGE followed by western blot with MBS7605215 (TRIM37 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 823669438
• NCBI GeneID: 4591
• Molecular Weight: 103,941 Da
• NCBI Official Full Name: TRIM37, partial
• NCBI Official Synonym Full Names: tripartite motif containing 37
• NCBI Official Symbol: TRIM37
• NCBI Official Synonym Symbols: MUL; POB1; TEF3
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM37
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM37
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRIM37
• UniProt Entry Name: TRI37_HUMAN

NCBI Description

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]

Uniprot Description

TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Oncoprotein; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cytoplasm; cytosol; ESC/E(Z) complex; perinuclear region of cytoplasm; peroxisome

Molecular Function: chromatin binding; ligase activity; protein binding; protein homodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of centriole replication; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; protein autoubiquitination; transcription, DNA-dependent

Disease: Mulibrey Nanism