ABCB8 cdna clone
ABCB8 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]
Protein type: Membrane protein, multi-pass; Transporter; Mitochondrial; Transporter, ABC family; Membrane protein, integral; Hydrolase
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: ATP-binding cassette (ABC) transporter complex; membrane; mitochondrial envelope; mitochondrion; nucleolus; nucleus
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity
Biological Process: transmembrane transport; transport
Research Articles on ABCB8
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Product Notes
The ABCB8 abcb8 (Catalog #AAA1272989) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTGGTGC ATTTATTTCG GGTCGGGATT CGGGGTGGCC CATTCCCAGG CAGGCTGCTA CCGCCCCTCC GCTTCCAGAC ATTCTCAGCT GTCAGGTACT CTGATGGCTA CCGCAGCTCC TCCCTCCTCC GGGCCGTGGC CCACCTGCGG TCCCAGCTCT GGGCCCACCT CCCTCGAGCC CCCCTAGCTC CCAGATGGAG CCCCTCTGCC TGGTGCTGGG TTGGGGGAGC CCTGCTAGGC CCCATGGTAC TGAGTAAGCA TCCCCACCTC TGCCTTGTGG CCCTGTGTGA GGCAGAAGAG GCCCCTCCTG CCAGCTCCAC ACCCCATGTC GTGGGGTCTC GCTTTAACTG GAAGCTCTTC TGGCAGTTTC TGCACCCCCA CCTGCTGGTC CTGGGGGTAG CCGTCGTGCT GGCCTTGGGT GCGGCACTCG TGAATGTACA GATCCCCCTG CTCCTGGGCC AGCTGGTAGA GGTCGTGGCC AAGTACACAA GGGACCACGT AGGGAGTTTC ATGACTGAGT CCCAGAATCT CAGCACCCAC CTGCTTATCC TCTATGGTGT CCAGGGACTG CTGACCTTCG GGTACCTGGT GCTGCTGTCC CACGTTGGCG AGCGCATGGC TGTGGACATG CGGAGGGCCC TCTTCAGCTC CCTGCTCCGA CAAGACATCA CCTTCTTTGA CGCCAATAAG ACAGGGCAGC TGGTGAGCCG CTTGACAACT GACGTGCAGG AGTTTAAGTC ATCCTTCAAG CTTGTCATCT CCCAGGGGCT GCGAAGCTGC ACCCAGGTGG CAGGCTGCCT GGTGTCCCTG TCCATGCTGT CGACACGCCT CACGCTGCTG CTGATGGTGG CCACACCAGC CCTGATGGGA GTGGGCACCC TGATGGGCTC AGGCCTCCGA AAATTGTCTC GCCAGTGTCA GGAGCAGATC GCCAGGGCAA TGGGCGTAGC AGACGAGGCC CTGGGCAATG TGCGGACTGT GCGTGCCTTC GCCATGGAGC AACGGGAAGA GGAGCGCTAT GGGGCAGAGC TGGAAGCCTG CCGCTGCCGG GCAGAGGAGC TGGGCCGCGG CATCGCCTTG TTCCAAGGGC TTTCCAACAT CGCCTTCAAC TGCATGGTCT TGGGTACCCT ATTTATTGGG GGCTCCCTTG TGGCCGGACA GCAGCTGACA GGGGGAGACC TCATGTCCTT CCTGGTGGCC TCCCAGACAG TGCAAAGGTC CATGGCCAAC CTCTCTGTCC TGTTTGGGCA GGTGGTCCGG GGGCTGAGTG CAGGTGCCCG GGTCTTTGAG TACATGGCCC TGAACCCCTG CATCCCACTG TCTGGGGGCT GCTGCGTCCC CAAAGAGCAG CTGCGTGGCT CCGTTACATT TCAGAACGTC TGCTTCAGCT ACCCCTGCCG CCCCGGCTTC GAGGTGCTGA AAGACTTCAC CCTGACGCTG CCCCCTGGCA AGATCGTGGC CCTCGTGGGC CAGTCTGGCG GAGGAAAGAC CACCGTGGCT TCCCTGCTGG AGCGCTTCTA CGACCCCACG GCAGGCGTGG TGATGCTGGA TGGGCGGGAC CTGCGCACCC TTGACCCCTC CTGGCTCCGG GGCCAGGTTG TCGGCTTCAT CAGCCAGGAG CCCGTCCTGT TTGGGACGAC CATCATGGAA AACATCCGCT TTGGGAAGCT GGAAGCTTCC GATGAAGAGG TGTACACAGC CGCCCGGGAA GCGAATGCTC ACGAGTTCAT CACCAGCTTC CCCGAGGGCT ACAACACGGT CGTCGGTGAA CGGGGCACTA CCCTGTCTGG GGGCCAGAAG CAGCGCCTGG CCATCGCCCG AGCCCTTATC AAGCAGCCCA CGGTGCTGAT ACTGGATGAA GCTACCAGCG CGCTGGATGC AGAGTCCGAG CGGGTTGTAC AGGAGGCCCT GGACCGGGCC AGTGCAGGCC GCACGGTGCT GGCTGGGACA CATGAAGAGC TCCTGAAGAA AGGCGGGCTA TACGCCGAGC TCATCCGGAG GCAGGCCCTG GATGCCCCGA GGACAGCGGC CCCACCGCCC AAAAAGCCAG AAGGCCCCAG GAGCCACCAG CACAAGTCCT GA. It is sometimes possible for the material contained within the vial of "ABCB8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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