UBR1 cdna clone
UBR1 cDNA Clone
Gene Names
UBR1; JBS
Synonyms
UBR1; UBR1 cDNA Clone; UBR1 cdna clone
Sequence
atggcggacgaggaggctggaggtactgagaggatggaaatcagcgcggagttaccccagacccctcagcgtctggcatcttggtgggatcagcaagttgatttttatactgctttcttgcatcatttggcacaattggtgccagaaatttactttgctgaaatggacccagacttggaaaagcaggaggaaagtgtacaaatgtcaatattcactccactggaatggtacttatttggagaagatccagatatttgcttagagaaattgaagcacagtggagcatttcagctttgtgggagggttttcaaaagtggagagacaacctattcttgcagggattgtgcaattgatccaacatgtgtactctgtatggactgcttccaggacagtgttcataaaaatcatcgttacaagatgcatacttctactggaggagggttctgtgactgtggagacacagaggcatggaaaactggccctttttgtgtaaatcatgaacctggaagagcaggtactataaaagagaattcacgctgtccgttgaatgaagaggtaattgtccaagccaggaaaatatttccttcagtgataaaatatgtcgtagaaatgactatatgggaagaggaaaaagaactgcctcctgaactccagataagggagaaaaatgaaagatactattgtgtccttttcaatgatgaacaccattcatatgaccacgtcatatacagcctacaaagagctcttgactgtgagctcgcagaggcccagttgcataccactgccattgacaaagagggtcgtcgggctgttaaagcgggagcttatgctgcttgccaggaagcaaaggaagatataaagagtcattcagaaaatgtctctcaacatccacttcatgtagaagtattacactcagagattatggctcatcagaaatttgctttgcgtcttggttcctggatgaacaaaattatgagctattcaagtgactttaggcagatcttttgccaagcatgccttagagaagaacctgactcggagaatccctgtctcataagcaggttaatgctttgggatgcaaagctttataaaggtgcccgtaagatccttcatgaattgatcttcagcagtttttttatggagatggaatacaaaaaactctttgctatggaatttgtgaagtattataaacaactgcagaaagaatatatcagtgatgatcatgacagaagtatctctataactgcactttcagttcagatgtttactgttcctactctggctcgacatcttattgaagagcagaatgttatctctgtcattactgaaactctgctagaagttttacctgagtacttggacaggaacaataaattcaacttccagggttatagccaggacaaattgggaagagtatatgcagtaatatgtgacctaaagtatatcctgatcagcaaacccacaatatggacagaaagattaagaatgcagttccttgaaggttttcgatcttttttgaagattcttacctgtatgcagggaatggaagaaatccgaagacaggttgggcaacacattgaagtggatcctgattgggaggctgccattgctatacagatgcaattgaagaatattttactcatgttccaagagtggtgtgcttgtgatgaagaactcttacttgtggcttataaagaatgtcacaaagctgtgatgaggtgcagtaccagtttcatatctagtagcaagacagtagtacaatcgtgtggacatagtttggaaacaaagtcctacagagtatctgaggatcttgtaagcatacatctgccactctctaggacccttgctggtcttcatgtacgtttaagcaggctgggtgctgtttcaagactgcatgaatttgtgtcttttgaggactttcaagtagaggtactagtggaatatcctttacgttgtctggtgttggttgcccaggttgttgctgagatgtggcgaagaaatggactgtctcttattagccaggtgttttattaccaagatgttaagtgcagagaagaaatgtatgataaagatatcatcatgcttcagattggtgcatctttaatggatcccaataagttcttgttactggtacttcagaggtatgaacttgccgaggcttttaacaagaccatatctacaaaagaccaggatttgattaaacaatataatacactaatagaagaaatgcttcaggtcctcatctatattgtgggtgagcgttatgtacctggagtgggaaatgtgaccaaagaagaggtcacaatgagagaaatcattcacttgctttgcattgaacccatgccacacagtgccattgccaaaaatttacctgagaatgaaaataatgaaactggcttagagaatgtcataaacaaagtggccacatttaagaaaccaggtgtatcaggccatggagtttatgaactaaaagatgaatcactgaaagacttcaatatgtacttttatcattactccaaaacccagcatagcaaggctgaacatatgcagaagaaaaggagaaaacaagaaaacaaagatgaagcattgccgccaccaccacctcctgaattctgccctgctttcagcaaagtgattaaccttctcaactgtgatatcatgatgtacattctcaggaccgtatttgagcgggcaatagacacagattctaacttgtggaccgaagggatgctccaaatggcttttcatattctggcattgggtttactagaagagaagcaacagcttcaaaaagctcctgaagaagaagtaacatttgacttttatcataaggcttcaagattgggaagttcagccatgaatatacaaatgcttttggaaaaactcaaaggaattccccagttagaaggccagaaggacatgataacgtggatacttcagatgtttgacacagtgaagcgattaagagaaaaatcttgtttaattgtagcaaccacatcaggatcggaatctattaagaatgatgagattactcatgataaagaaaaagcagaacgaaaaagaaaagctgaagctgctaggctacatcgccagaagatcatggctcagatgtctgccttacagaaaaacttcattgaaactcataaactcatgtatgacaatacatcagaaatgcctgggaaagaagattccattatggaggaagagagcaccccagcagtcagtgactactctagaattgctttgggtcctaaacggggtccatctgttactgaaaaggaggtgctgacgtgcatcctttgccaagaagaacaggaggtgaaaatagaaaataatgccatggtattatcggcctgtgtccagaaatctactgccttaacccagcacaggggaaaacccatagaactctcaggagaagccctagacccacttttcatggatccagacttggcatatggaacttatacaggaagctgtggtcatgtaatgcacgcagtgtgctggcagaagtattttgaagctgtacagctgagctctcagcagcgcattcatgttgacctttttgacttggaaagtggagaatatctttgccctctttgcaaatctctgtgcaatactgtgatccccattattcctttgcaacctcaaaagataaacagtgagaatgcagatgctcttgctcaacttttgaccctggcacggtggatacagactgttctggccagaatatcaggttataatataagacatgctaaaggagaaaacccaattcctattttctttaatcaaggaatgggagattctactttggagttccattccatcctgagttttggcgttgagtcttcgattaaatattcaaatagcatcaaggaaatggttattctctttgccacaacaatttatagaattggattgaaagtgccacctgatgaaagggatcctcgagtccccatgctgacctggagcacctgcgctttcactatccaggcaattgaaaatctattgggagatgaaggaaaacctctgtttggagcacttcaaaataggcagcataatggtctgaaagcattaatgcagtttgcagttgcacagaggattacctgtcctcaggtcctgatacagaaacatctggttcgtcttctatcagttgttcttcctaacataaaatcagaagatacaccatgccttctgtctatagatctgtttcatgttttggtgggtgctgtgttagcattcccatccttgtattgggatgaccctgttgatctgcagccttcttcagttagttcttcctataaccacctttatctcttccatttgatcaccatggcacacatgcttcagatactacttacagtagacacaggcctaccccttgctcaggttcaagaagacagtgaagaggctcattccgcatcttctttctttgcagaaatttctcaatatacaagtggctccattgggtgtgatattcctggctggtatttgtgggtctcactgaagaatggcatcaccccttatcttcgctgtgctgcattgtttttccactatttacttggggtaactccgcctgaggaactgcataccaattctgcagaaggagagtacagtgcactctgtagctatctatctttacctacaaatttgttcctgctcttccaggaatattgggatactgtaaggcccttgctccagaggtggtgtgcagatcctgccttactaaactgtttgaagcaaaaaaacaccgtggtcaggtaccctagaaaaagaaatagtttgatagagcttcctgatgactatagctgcctcctgaatcaagcttctcatttcaggtgcccacggtctgcagatgatgagcgaaagcatcctgtcctctgccttttctgtggggctatactatgttctcagaacatttgctgccaggaaattgtgaacggggaagaggttggagcttgcatttttcacgcacttcactgtggagccggagtctgcattttcctaaaaatcagagaatgccgagtggtcctggttgaaggtaaagccagaggctgtgcctatccagctccttacttggatgaatatggagaaacagaccctggcctgaagaggggcaacccccttcatttatctcgtgagcggtatcggaagctccatttggtctggcaacaacactgcattatagaagagattgctaggagccaagagactaatcagatgttatttggattcaactggcagttactgtga
Sequence Length
5250
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
93,184 Da
NCBI Official Full Name
Homo sapiens ubiquitin protein ligase E3 component n-recognin 1, mRNA
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 1
NCBI Official Symbol
UBR1
NCBI Official Synonym Symbols
JBS
NCBI Protein Information
E3 ubiquitin-protein ligase UBR1
UniProt Protein Name
E3 ubiquitin-protein ligase UBR1
Protein Family
UniProt Gene Name
UBR1
UniProt Entry Name
UBR1_HUMAN
NCBI Description
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Uniprot Description
UBR1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS). This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine- onset destructive pancreatitis. Belongs to the UBR1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 15q13
Cellular Component: cytoplasm; ubiquitin ligase complex
Biological Process: negative regulation of TOR signaling pathway
Disease: Johanson-blizzard Syndrome
Research Articles on UBR1
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Product Notes
The UBR1 ubr1 (Catalog #AAA1272591) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggacg aggaggctgg aggtactgag aggatggaaa tcagcgcgga gttaccccag acccctcagc gtctggcatc ttggtgggat cagcaagttg atttttatac tgctttcttg catcatttgg cacaattggt gccagaaatt tactttgctg aaatggaccc agacttggaa aagcaggagg aaagtgtaca aatgtcaata ttcactccac tggaatggta cttatttgga gaagatccag atatttgctt agagaaattg aagcacagtg gagcatttca gctttgtggg agggttttca aaagtggaga gacaacctat tcttgcaggg attgtgcaat tgatccaaca tgtgtactct gtatggactg cttccaggac agtgttcata aaaatcatcg ttacaagatg catacttcta ctggaggagg gttctgtgac tgtggagaca cagaggcatg gaaaactggc cctttttgtg taaatcatga acctggaaga gcaggtacta taaaagagaa ttcacgctgt ccgttgaatg aagaggtaat tgtccaagcc aggaaaatat ttccttcagt gataaaatat gtcgtagaaa tgactatatg ggaagaggaa aaagaactgc ctcctgaact ccagataagg gagaaaaatg aaagatacta ttgtgtcctt ttcaatgatg aacaccattc atatgaccac gtcatataca gcctacaaag agctcttgac tgtgagctcg cagaggccca gttgcatacc actgccattg acaaagaggg tcgtcgggct gttaaagcgg gagcttatgc tgcttgccag gaagcaaagg aagatataaa gagtcattca gaaaatgtct ctcaacatcc acttcatgta gaagtattac actcagagat tatggctcat cagaaatttg ctttgcgtct tggttcctgg atgaacaaaa ttatgagcta ttcaagtgac tttaggcaga tcttttgcca agcatgcctt agagaagaac ctgactcgga gaatccctgt ctcataagca ggttaatgct ttgggatgca aagctttata aaggtgcccg taagatcctt catgaattga tcttcagcag tttttttatg gagatggaat acaaaaaact ctttgctatg gaatttgtga agtattataa acaactgcag aaagaatata tcagtgatga tcatgacaga agtatctcta taactgcact ttcagttcag atgtttactg ttcctactct ggctcgacat cttattgaag agcagaatgt tatctctgtc attactgaaa ctctgctaga agttttacct gagtacttgg acaggaacaa taaattcaac ttccagggtt atagccagga caaattggga agagtatatg cagtaatatg tgacctaaag tatatcctga tcagcaaacc cacaatatgg acagaaagat taagaatgca gttccttgaa ggttttcgat cttttttgaa gattcttacc tgtatgcagg gaatggaaga aatccgaaga caggttgggc aacacattga agtggatcct gattgggagg ctgccattgc tatacagatg caattgaaga atattttact catgttccaa gagtggtgtg cttgtgatga agaactctta cttgtggctt ataaagaatg tcacaaagct gtgatgaggt gcagtaccag tttcatatct agtagcaaga cagtagtaca atcgtgtgga catagtttgg aaacaaagtc ctacagagta tctgaggatc ttgtaagcat acatctgcca ctctctagga cccttgctgg tcttcatgta cgtttaagca ggctgggtgc tgtttcaaga ctgcatgaat ttgtgtcttt tgaggacttt caagtagagg tactagtgga atatccttta cgttgtctgg tgttggttgc ccaggttgtt gctgagatgt ggcgaagaaa tggactgtct cttattagcc aggtgtttta ttaccaagat gttaagtgca gagaagaaat gtatgataaa gatatcatca tgcttcagat tggtgcatct ttaatggatc ccaataagtt cttgttactg gtacttcaga ggtatgaact tgccgaggct tttaacaaga ccatatctac aaaagaccag gatttgatta aacaatataa tacactaata gaagaaatgc ttcaggtcct catctatatt gtgggtgagc gttatgtacc tggagtggga aatgtgacca aagaagaggt cacaatgaga gaaatcattc acttgctttg cattgaaccc atgccacaca gtgccattgc caaaaattta cctgagaatg aaaataatga aactggctta gagaatgtca taaacaaagt ggccacattt aagaaaccag gtgtatcagg ccatggagtt tatgaactaa aagatgaatc actgaaagac ttcaatatgt acttttatca ttactccaaa acccagcata gcaaggctga acatatgcag aagaaaagga gaaaacaaga aaacaaagat gaagcattgc cgccaccacc acctcctgaa ttctgccctg ctttcagcaa agtgattaac cttctcaact gtgatatcat gatgtacatt ctcaggaccg tatttgagcg ggcaatagac acagattcta acttgtggac cgaagggatg ctccaaatgg cttttcatat tctggcattg ggtttactag aagagaagca acagcttcaa aaagctcctg aagaagaagt aacatttgac ttttatcata aggcttcaag attgggaagt tcagccatga atatacaaat gcttttggaa aaactcaaag gaattcccca gttagaaggc cagaaggaca tgataacgtg gatacttcag atgtttgaca cagtgaagcg attaagagaa aaatcttgtt taattgtagc aaccacatca ggatcggaat ctattaagaa tgatgagatt actcatgata aagaaaaagc agaacgaaaa agaaaagctg aagctgctag gctacatcgc cagaagatca tggctcagat gtctgcctta cagaaaaact tcattgaaac tcataaactc atgtatgaca atacatcaga aatgcctggg aaagaagatt ccattatgga ggaagagagc accccagcag tcagtgacta ctctagaatt gctttgggtc ctaaacgggg tccatctgtt actgaaaagg aggtgctgac gtgcatcctt tgccaagaag aacaggaggt gaaaatagaa aataatgcca tggtattatc ggcctgtgtc cagaaatcta ctgccttaac ccagcacagg ggaaaaccca tagaactctc aggagaagcc ctagacccac ttttcatgga tccagacttg gcatatggaa cttatacagg aagctgtggt catgtaatgc acgcagtgtg ctggcagaag tattttgaag ctgtacagct gagctctcag cagcgcattc atgttgacct ttttgacttg gaaagtggag aatatctttg ccctctttgc aaatctctgt gcaatactgt gatccccatt attcctttgc aacctcaaaa gataaacagt gagaatgcag atgctcttgc tcaacttttg accctggcac ggtggataca gactgttctg gccagaatat caggttataa tataagacat gctaaaggag aaaacccaat tcctattttc tttaatcaag gaatgggaga ttctactttg gagttccatt ccatcctgag ttttggcgtt gagtcttcga ttaaatattc aaatagcatc aaggaaatgg ttattctctt tgccacaaca atttatagaa ttggattgaa agtgccacct gatgaaaggg atcctcgagt ccccatgctg acctggagca cctgcgcttt cactatccag gcaattgaaa atctattggg agatgaagga aaacctctgt ttggagcact tcaaaatagg cagcataatg gtctgaaagc attaatgcag tttgcagttg cacagaggat tacctgtcct caggtcctga tacagaaaca tctggttcgt cttctatcag ttgttcttcc taacataaaa tcagaagata caccatgcct tctgtctata gatctgtttc atgttttggt gggtgctgtg ttagcattcc catccttgta ttgggatgac cctgttgatc tgcagccttc ttcagttagt tcttcctata accaccttta tctcttccat ttgatcacca tggcacacat gcttcagata ctacttacag tagacacagg cctacccctt gctcaggttc aagaagacag tgaagaggct cattccgcat cttctttctt tgcagaaatt tctcaatata caagtggctc cattgggtgt gatattcctg gctggtattt gtgggtctca ctgaagaatg gcatcacccc ttatcttcgc tgtgctgcat tgtttttcca ctatttactt ggggtaactc cgcctgagga actgcatacc aattctgcag aaggagagta cagtgcactc tgtagctatc tatctttacc tacaaatttg ttcctgctct tccaggaata ttgggatact gtaaggccct tgctccagag gtggtgtgca gatcctgcct tactaaactg tttgaagcaa aaaaacaccg tggtcaggta ccctagaaaa agaaatagtt tgatagagct tcctgatgac tatagctgcc tcctgaatca agcttctcat ttcaggtgcc cacggtctgc agatgatgag cgaaagcatc ctgtcctctg ccttttctgt ggggctatac tatgttctca gaacatttgc tgccaggaaa ttgtgaacgg ggaagaggtt ggagcttgca tttttcacgc acttcactgt ggagccggag tctgcatttt cctaaaaatc agagaatgcc gagtggtcct ggttgaaggt aaagccagag gctgtgccta tccagctcct tacttggatg aatatggaga aacagaccct ggcctgaaga ggggcaaccc ccttcattta tctcgtgagc ggtatcggaa gctccatttg gtctggcaac aacactgcat tatagaagag attgctagga gccaagagac taatcagatg ttatttggat tcaactggca gttactgtga. It is sometimes possible for the material contained within the vial of "UBR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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