NONO cdna clone
NONO cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
Uniprot Description
NONO: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Together with PSPC1, required for the formation of nuclear paraspeckles. A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.
Protein type: Nucleolus; RNA-binding; RNA splicing; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: membrane; nuclear matrix; nucleoplasm; nucleus; paraspeckles
Molecular Function: chromatin binding; identical protein binding; protein binding
Biological Process: circadian rhythm; mRNA processing; negative regulation of transcription, DNA-dependent; nuclear mRNA splicing, via spliceosome; regulation of circadian rhythm; regulation of transcription, DNA-dependent; RNA splicing
Disease: Mental Retardation, X-linked, Syndromic 34
Research Articles on NONO
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Product Notes
The NONO nono (Catalog #AAA1272239) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagagta ataaaacttt taacttggag aagcaaaacc atactccaag aaagcatcat caacatcacc accagcagca gcaccaccag cagcaacagc agcagccgcc accaccgcca atacctgcaa atgggcaaca ggccagcagc caaaatgaag gcttgactat tgacctgaag aattttagaa aaccaggaga gaagaccttc acccaacgaa gccgtctttt tgtgggaaat cttcctcccg acatcactga ggaagaaatg aggaaactat ttgagaaata tggaaaggca ggcgaagtct tcattcataa ggataaagga tttggcttta tccgcttgga aacccgaacc ctagcggaga ttgccaaagt ggagctggac aatatgccac tccgtggaaa gcagctgcgt gtgcgctttg cctgccatag tgcatccctt acagttcgaa accttcctca gtatgtgtcc aacgaactgc tggaagaagc cttttctgtg tttggccagg tagagagggc tgtagtcatt gtggatgatc gaggaaggcc ctcaggaaaa ggcattgttg agttctcagg gaagccagct gctcggaaag ctctggacag atgcagtgaa ggctccttcc tgctaaccac atttcctcgt cctgtgactg tggagcccat ggaccagtta gatgatgaag agggacttcc agagaagctg gttataaaaa accagcaatt tcacaaggaa cgagagcagc cacccagatt tgcacagcct ggctcctttg agtatgaata tgccatgcgc tggaaggcac tcattgagat ggagaagcag cagcaggacc aagtggaccg caacatcaag gaggctcgtg agaagctgga gatggagatg gaagctgcac gccatgagca ccaggtcatg ctaatgagac aggatttgat gaggcgccaa gaagaacttc ggaggatgga agagctgcac aaccaagagg tgcaaaaacg aaagcaactg gagctcaggc aggaggaaga gcgcaggcgc cgtgaagaag agatgcggcg gcagcaagaa gaaatgatgc ggcgacagca ggaaggattc aagggaacct tccctgatgc gagagagcag gagattcgga tgggtcagat ggctatggga ggtgctatgg gcataaacaa cagaggtgcc atgccccctg ctcctgtgcc agctggtacc ccagctcctc caggacctgc cactatgatg ccggatggaa ctttgggatt gaccccacca acaactgaac gctttggtca ggctgctaca atggaaggaa ttggggcaat tggtggaact cctcctgcat tcaaccgtgc agctcctgga gctgaatttg ccccaaacaa acgtcgccga tactaa. It is sometimes possible for the material contained within the vial of "NONO, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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